The CISOE-A classification compared with the Bethesda 2001 and Pap classifications
| S | O | E | Pap | Description | Bethesda 2001 | |
|---|---|---|---|---|---|---|
| AGC, atypical glandular cells; AIS, endocervical adenocarcinoma in situ; ASC-H, atypical squamous cells cannot exclude HSIL; ASC-US, atypical squamous cells of undetermined significance; CIN, cervical intraepithelial neoplasia; HSIL, high grade squamous intraepithelial lesion, encompassing CIN2–3; LSIL, low grade squamous intraepithelial lesion, encompassing CIN1. | ||||||
| 0 | 0 | 0 | 0 | Inadequate | Unsatisfactory for evaluation | |
| 1 | 1 | 1–2 | 1 | Normal | Negative for intraepithelial lesion or malignancy | |
| 1 | 2 | 1–2 | 1 | Normal | Atrophy, negative for intraepithelial lesion or malignancy | |
| 2–3 | 3 | 3 | 2 | Borderline dyskaryosis | ASC-US/ASC-H | AGC |
| 4 | 4 | 4 | 3a1 | Mild dyskaryosis | ASC-H/LSIL | AGC favour neoplastic |
| 5 | 5 | 5 | 3a2 | Moderate dyskaryosis | HSIL | AGC favour neoplastic |
| 6 | 6 | 6 | 3b | Severe dyskaryosis | HSIL | AGC favour neoplastic |
| 7 | − | 7 | 4 | Carcinoma in situ | HSIL | AIS |
| 8–9 | 7–8 | 9 | 5 | Carcinoma | Squamous cell carcinoma | Adenocarcinoma |