Categorisation of 2550 blood film samples submitted to a single unit for examination of blood films for presence of vacuolated lymphocytes
| Indication group | N (% of total) | Median age (range) | Frequency vacuolated lymphocytes (%) | Frequency compared with overall |
|---|---|---|---|---|
| *p <0.05. | ||||
| No clinical details | 729 (28.6) | 3 (0–86) | 66/729 (9.1%)* | Z = −2.78, p<0.01 |
| Developmental regression/delay | 559 (21.9) | 2 (0–59) | 17/559 (3.0%)* | Z = 2.87, p<0.01 |
| Seizures | 305 (12.0) | 3 (0–81) | 6/305 (2.0%)* | Z = 2.96, p<0.01 |
| Ataxia/dystonia | 283 (11.1) | 6 (0–88) | 11/283 (3.9%) | Z = 1.51, p = 0.11 |
| Cardiomyopathy | 224 (8.8) | 0 (0–57) | 11/224 (4.9%) | Z = 0.73, p = 0.47 |
| Miscellaneous | 197 (7.7) | 0 (0–79) | 9/197 (4.6%) | Z = 0.88, p = 0.36 |
| Hepatosplenomegaly | 109 (4.3) | 0 (0–36) | 10/109 (9.2%) | Z = −1.29, p = 0.16 |
| Ophthalmic | 64 (2.5) | 7 (0–29) | 19/64 (39.7%)* | Z = −7.45, p<0.0001 |
| Family history | 45 (1.8) | 5 (0–25) | 6/45 (13.3%)* | Z = −1.98, p = 0.04 |
| Failure to thrive | 28 (1.0) | 0 (0–8) | 0/28 (0%) | Z = 1.40, p = 0.14 |
| Respiratory failure | 7 (0.3) | 39 (0–78) | 1/7 (14.2%) | Z = −0.90, p = 0.21 |
| Overall | 2550 (100) | 2 (0–88) | 156/2550 (6.5%) | |