Cross tabulation between molecular genetic changes and blood vessel and perineural involvement and micrometastases, controlling for the number of lymph nodes removed
| Molecular genetic changes | Blood vessel involvement | Perineural involvement | Micrometastasis | |||
|---|---|---|---|---|---|---|
| N* | %† | N* | %† | N* | %† | |
| *The number of carcinomas listed with each histological change is less than the total number studied because some lesions had incomplete data or were uninformative; †reflects the percentage of carcinomas with information about the listed histological change and also with or without the particular molecular change. | ||||||
| APC, adenomatous polyposis coli; CI, confidence interval; DCC, deleted in colon cancer; LOH, loss of heterozygosity; RR, relative risk. | ||||||
| APC | ||||||
| LOH | 15/44 | 34% | 4/44 | 9% | 16/40 | 40% |
| No LOH | 17/57 | 30% | 2/56 | 4% | 22/53 | 42% |
| RR | 1.21 | 2.70 | 0.90 | |||
| p Value | 0.65 | 0.25 | 0.82 | |||
| CI | 0.52 to 2.82 | 0.47 to 15.48 | 0.38 to 2.16 | |||
| Ki-ras | ||||||
| Mutated | 11/40 | 28% | 1/38 | 3% | 9/34 | 26% |
| Wild-type | 28/78 | 36% | 7/79 | 9% | 34/72 | 47% |
| RR | 0.69 | 0.28 | 0.44 | |||
| p Value | 0.39 | 0.23 | 0.08 | |||
| CI | 0.30 to 1.60 | 0.03 to 2.42 | 0.18 to 1.11 | |||
| DCC | ||||||
| LOH | 17/63 | 27% | 4/64 | 6% | 24/57 | 42% |
| No LOH | 14/27 | 52% | 2/26 | 8% | 7/25 | 28% |
| RR | 0.34 | 0.80 | 1.72 | |||
| p Value | 0.02 | 0.81 | 0.33 | |||
| CI | 0.13 to 0.89 | 0.14 to 4.66 | 0.58 to 5.07 | |||
| Microsatellite | ||||||
| Unstable | 7/16 | 44% | ||||
| Stable | 36/90 | 40% | ||||
| RR | 0.89 | |||||
| p Value | 0.85 | |||||
| CI | 0.29 to 2.79 | |||||