Associations between HIF-1α staining pattern, grade, and expression of CA IX and GLUT-1 for HIF-1α positive breast cancer cases (n = 88)
| n | HIF-1α staining pattern* | p Value (χ2) | ||
|---|---|---|---|---|
| Diffuse | Necrotic | |||
| *One case, which was grouped with the perinecrotic cases, showed both diffuse and perinecrotic expression. | ||||
| CA IX, carbonic anhydrase IX; GLUT-1, glucose transporter 1; HIF-1α, hypoxia inducible factor 1α. | ||||
| Grade | ||||
| I | 15 | 13 | 2 | |
| II | 30 | 25 | 5 | |
| III | 43 | 23 | 20 | 0.007 |
| CA IX | ||||
| Negative | 67 | 55 | 12 | |
| Positive | 21 | 6 | 15 | <0.001 |
| GLUT-1 | ||||
| Negative | 46 | 41 | 5 | |
| Positive | 42 | 20 | 22 | <0.001 |