Univariate analysis of survival in 84 patients with OSCC according to the Cox proportional hazards model
| Variables | Hazards ratio | 95% CI | p Value |
|---|---|---|---|
| 1 B/w,1 bottle (360 ml; 25% alcohol)/week; CI, confidence interval; F, female; LN, lymph node; M, male; OSCC, oral squamous cell carcinoma; p-Akt, phosphorylated Akt; PCNA LI, proliferating cell nuclear antigen labelling index; VEGF, vascular endothelial growth factor. | |||
| Age (⩽60/>60) | 1.954 | 0.954 to 3.999 | 0.067 |
| Sex (M/F) | 0.732 | 0.317 to 1.694 | 0.3467 |
| Smoking (yes/no) | 2.030 | 0.992 to 4.156 | 0.053 |
| Alcohol (<1 B/w/⩾1 B/w) | 1.192 | 0.596 to 2.385 | 0.619 |
| Differentiation (well/moderate, poor) | 2.106 | 1.037 to 4.275 | 0.039 |
| Tumour size (T1, T2/T3, T4) | 2.899 | 1.426 to 5.895 | 0.003 |
| LN metastasis (positive/negative) | 2.875 | 1.429 to 5.784 | 0.003 |
| Clinical stage (I, II/III,IV) | 3.383 | 1.557 to 7.352 | 0.002 |
| Recurrence (yes/no) | 2.595 | 1.291 to 5.214 | 0.007 |
| p-AKT expression (+/−) | 3.219 | 1.594 to 6.505 | 0.001 |
| E-cadherin expression (+/−) | 0.414 | 0.196 to 0.875 | 0.021 |
| VEGF expression (+/−) | 1.805 | 0.780 to 4.176 | 0.168 |
| PCNA LI | 1.022 | 1.000 to 1.044 | 0.049 |