Chromosome locus | Putative genes | Normal function of gene | Status of gene in prostate cancer | Ref |
---|---|---|---|---|
EGFR, epidermal growth factor receptor; PTEN, phosphatase and tensin homologue; Rb, retinoblastoma. | ||||
7p | EGFR | Growth factor | Amplified | 39 |
7q | CAV 1 | Structural protein of caveolae membranes in fibroblasts >and endothelia | Amplified | 40 |
8p | MSR | Encodes a macrophage scavenger receptor responsible >for cellular uptake of molecules including bacterial cell >wall products | Deleted | 41 |
8p | NKX3–1 | Tumour suppressor gene | Deleted | 42 |
8q | c-myc | Transcriptional activator | Amplified | 43 |
10q | PTEN | Tumour suppressor gene | Mutated | 44 |
13q | Rb | Tumour suppressor gene | Deleted | 45 |
16q | E-CAD | Adhesion molecule | Deleted | 46 |
Xq | AR | Androgen receptor | Amplified | 47 |