Semiquantitative and quantitative scores of insulin-like growth factor binding protein 2 expression in benign and malignant human breast tissue
| Semiquantitative | Quantitative | |
|---|---|---|
| Values are mean (SEM). | ||
| Group I | ||
| Normal breast tissue | 0.18 (0.12) | 0.06 (0.03) |
| Non-proliferative fibrocystic change | 0.17 (0.11) | 0.09 (0.05) |
| Hyperplasia | 0.67 (0.17) | 0.58 (0.15) |
| Group II | ||
| Atypical hyperplasia | 1.27 (0.19) | 1.99 (0.45) |
| Carcinoma in situ | 1.92 (0.18) | 3.42 (0.49) |
| Group III | ||
| Ductal carcinoma, grade I | 2.94 (0.18) | 7.33 (0.96) |
| Ductal carcinoma, grade II | 3.58 (0.14) | 11.59 (0.93) |
| Ductal carcinoma, grade III | 3.33 (0.16) | 11.52 (0.97) |
| Lobular carcinoma | 3.15 (0.19) | 9.56 (1.08) |
| Dunnett’s test | p Value | |
| Group I v group II | <0.001 | <0.001 |
| Group II v group III | <0.001 | <0.001 |
| Group I v group III | <0.001 | <0.001 |