Abstract P16
| Animal group | Body weight (g) | ITT plasma glucose mean fall AUC (mmol/l) | CTGF intact protein (% of control) | CTGF fragment to intact ratio (% of control) | CTGF mRNA (% of control) |
|---|---|---|---|---|---|
| Data are mean (SEM). | |||||
| *p<0.05 v PVG/c +vehicle group; †p<0.05 v each PVG/c group; ‡p<0.05 v PEPCK +vehicle; all analysis is by multiple ANOVA. | |||||
| AUC, area under the curve; CTGF, connective tissue growth factor; ITT, insulin tolerance test; PEPCK, rats overexpressing phosphoenolpyruvate carboxykinase; pio, pioglitazone; PVG/c, control rats. | |||||
| PVG/c +vehicle | 374 (5.4) | 1.67 (0.34) | 100 | 100 | 100 |
| PVG/c +pio | 373 (5.0) | 2.41 (0.52) | 194 (48)* | 86 (20.1) | 215 (36)* |
| PEPCK +vehicle | 411 (12.0)† | 1.47 (0.25) | 81 (31) | 146 (20.0)† | 265 (28)* |
| PEPCK +pio | 450 (5.4)†‡ | 2.51 (0.48)‡ | 158 (3)‡ | 68 (12.4)†‡ | 193 (25)*† |