Case | Clinicopathological features | Invasion of the adjacent structures | Bcl-2 IRS | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Age | Sex | Site | Type | MF | LCN | EEC | TV | EOE | Sclera | CB | ON | Normal | Tumour | |
Cases 1–12 and 13–24 are tumours with and without Bcl-2 protein expression, respectively. | ||||||||||||||
CB, ciliary body; ECM, epithelioid cell type; EEC, extension through the emissary canal; EOE, extraocular extension; IRS, immunoreactivity score; JPM, juxtapapillary melanoma; L, left; LCN, long ciliary nerve; MCM, mixed cell type; MF, mitotic figures (number of mitotic figures/40 high power fields); ON, optic nerve; R, right; TV, tumour cells in vascular lakes; –, absent; +; present. | ||||||||||||||
The Bcl-2 reactivity in normal tissues is the average reactivity (summed together) in corneal epithelium, endothelium, lens epithelium, several layers of the retinal cells, and the ciliary body. | ||||||||||||||
1 | 53 | M | L | MCM | 0 | – | – | – | – | – | – | – | 3 | 12 |
2 | 54 | M | L | MCM | 2 | – | + | – | – | – | – | – | 1.7 | 8 |
3 | 64 | M | L | MCM | 3 | – | + | – | – | – | – | – | 3.1 | 8 |
4 | 46 | M | L | MCM | 2 | – | – | – | – | – | – | – | 2 | 12 |
5 | 50 | M | L | MCM | 0 | – | – | – | – | – | – | – | 2.3 | 9 |
6 | 64 | F | R | ECM | 2 | – | + | + | – | – | – | – | 3.1 | 12 |
7 | 64 | F | R | MCM | 0 | – | + | – | – | – | – | – | 1.7 | 9 |
8 | 56 | M | R | MCM | 2 | – | – | – | – | – | – | – | 1.7 | 9 |
9 | 57 | F | L | MCM | 0 | – | – | + | – | – | – | – | 2 | 8 |
10 | 62 | M | R | MCM | 0 | – | – | – | – | – | – | – | 1.7 | 6 |
11 | 60 | M | R | ECM | 0 | – | – | – | – | – | – | – | 2 | 8 |
12 | 50 | M | R | ECM | 0 | – | – | – | – | – | – | – | 1.7 | 8 |
13 | 97 | M | R | MCM | 0 | + | – | – | – | – | – | – | 1.7 | 0.0 |
14 | 69 | M | R | MCM | 0 | – | + | – | – | + | – | – | 3.1 | 0.0 |
15 | 72 | M | R | MCM | 0 | – | – | – | – | – | – | – | 1.7 | 0.0 |
16 | 73 | F | L | MCM | 0 | – | – | – | – | – | – | – | 2 | 0.0 |
17 | 52 | M | R | ECM | 0 | – | – | – | – | – | + | – | 2 | 0.0 |
18 | 67 | M | L | MCM | 0 | – | – | – | – | – | – | – | 1.7 | 0.0 |
19 | 71 | F | L | MCM | 2 | – | – | + | – | – | – | – | 2.3 | 0.0 |
20 | 34 | M | L | JPM | 0 | – | + | + | – | – | – | – | 1.7 | 0.0 |
21 | 66 | M | L | MCM | 0 | – | – | – | – | – | – | + | 3 | 0.0 |
22 | 65 | F | L | MCM | 0 | – | – | – | – | – | – | – | 3 | 0.0 |
23 | 66 | M | L | MCM | 0 | – | – | – | – | – | – | – | 2 | 0.0 |
24 | 71 | M | R | MCM | 0 | – | – | – | – | – | – | – | 1.7 | 0.0 |