Factors predicting HER-2/neu overexpression* in primary operable breast cancers (n = 1362): multivariate analysis
| Odds ratio† (95% CI) | p Value | |
|---|---|---|
| *HER-2/neu was defined as negative when the DAKO score was 0, 1+, or 2+ and positive when 3+; †odds ratio adjusted for all variables in table; ‡ER and PR were defined as negative when the H score was ⩽50, and positive when 51–300. | ||
| CI, confidence interval; ER, oestrogen receptor; PR, progesterone receptor. | ||
| ER status‡ (negative v positive) | 2.16 (1.34 to 3.51) | 0.002 |
| PR status‡ (negative v positive) | 1.74 (1.10 to 2.78) | 0.019 |
| Tumour grade (grade 3 v 1–2) | 3.27 (2.12 to 5.05) | <0.001 |
| Tumour size (>20 mm v ⩽20 mm) | – | 0.351 |
| Lymph node (positive v negative) | – | 0.646 |
| Age (>50 years v ⩽50 years) | – | 0.989 |