Factors predicting HER-2/neu overexpression* in primary operable breast cancers (n = 1362): multivariate analysis
| Odds ratio† (95% CI) | p Value | |
|---|---|---|
| *HER-2/neu was defined as negative when the DAKO score was 0 or 1+, and positive when 2+ or 3+; †odds ratio adjusted for all variables in table; ‡ER and PR were defined as negative when the H score was ⩽50, and positive when 51–300. | ||
| CI, confidence interval; ER, oestrogen receptor; PR, progesterone receptor. | ||
| ER status‡ (negative versus positive) | 1.56 (1.03 to 2.35) | 0.034 |
| PR status‡ (negative v positive) | 1.51 (1.10 to 2.25) | 0.014 |
| Tumour grade (grade 3 v 1–2) | 2.15 (1.81 to 3.48) | <0.001 |
| Tumour size (>20 v ⩽20 mm) | – | 0.670 |
| Lymph node (positive v negative) | – | 0.178 |
| Age (>50 v ⩽50 years) | – | 0.736 |