Pathology, MSI, and MSH2/MLH1 protein expression (by immunohistochemistry) in the 11 MSI cases
| Case | Pathology | Microsatellite markers | MSI | Immunohistochemistry | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| BAT25 | BAT26 | D5S346 | D2S123 | D17S250 | D3S1317 | MSH2 | MLH1 | |||
| *MSI cases in which invasive adenocarcinoma was histologically diagnosed during short term follow up. | ||||||||||
| MSI, microsatellite instability; MSI-H/L, high/low frequency of microsatellite instability; MSS, microsatellite stable; NA, not assessable; NiN, non-invasive neoplasia. | ||||||||||
| C5 | Indefinite for NiN | – | – | MSI | – | MSI | MSI | MSI-H | Positive | Negative |
| C14 | Indefinite for NiN | – | – | – | – | – | MSI | MSI-L | Positive | Positive |
| C190 | Indefinite for NiN | – | – | – | MSI | – | – | MSI-L | Positive | Positive |
| C20 | Indefinite for NiN | – | – | MSI | NA | – | NA | MSI-L | Positive | Positive |
| C31 | Indefinite for NiN | – | – | – | – | MSI | – | MSI-L | Positive | Positive |
| C18 | Low grade NiN | – | – | NA | MSI | – | NA | MSI-L | Negative | Positive |
| C7 | Low grade NiN | – | NA | NA | MSI | MSI | NA | MSI-H | Positive | Negative |
| C26 | Low grade NiN | MSI | MSI | MSI | – | MSI | MSI | MSI-H | Negative | Positive |
| C9 | High grade NiN | – | – | NA | NA | MSI | NA | MSI-L | Positive | Positive |
| C6* | High grade NiN | – | – | MSI | MSI | – | – | MSI-H | Negative | Positive |
| C12* | High grade NiN | MSI | MSI | MSI | – | MSI | MSI | MSI-H | Positive | Negative |