Clinical data, probes used, and FISH results
| Patient | Sample | Clinical status* | FISH analysis† | Final Dx | ||
|---|---|---|---|---|---|---|
| Probe | Pattern | Result | ||||
| *Figures in parenthesis show the time in months from diagnosis; †cf table 2; ‡atypical FISH pattern. | ||||||
| B-CLL, B chronic lymphocytic leukaemia; BM, bone marrow; CNS, central nervous system; DLBCL, diffuse large B cell lymphoma; Dx, diagnosis; FISH, fluorescence in situ hybridisation; FL, follicular lymphoma; F-up, follow up; HIV, human immunodeficiency virus; LN, lymph node; MCL, mantle cell lymphoma; MZL, marginal zone lymphoma; NE, not evaluated; Rel, relapse. | ||||||
| 1 | LN | Dx | t(11;14) | 1R1G2F (78%) | + | MCL |
| 2 | Intestine | Rel (+68) | t(11;14) | 1R1G6F (100%) | +‡ | MCL |
| 3 | Soft tissue | Dx | t(11;14) | 1R1G2F (100%) | + | MCL |
| LN | Rel (+10) | t(11;14) | 1R1G2F (90.4%) | + | ||
| 4 | LN | Dx | t(11;14) | 1R1G2F (46.4%) | + | MCL |
| 5 | Soft tissue | Dx | t(11;14) | 1R1G2F (75%) | + | MCL |
| 6 | LN | Dx | t(11;14) | 2R2G | − | MCL |
| 7 | BM | Dx | t(14;18) | 2R3G (6.6%) | −‡ | |
| BM | Dx | t(11;14) | 1R1G2F (6%) | + | MCL | |
| LN | Rel (+70) | t(14;18) | 2R4G (63%) | −‡ | ||
| LN | Rel (+70) | t(11;14) | 1R2G2F (100%) | +‡ | ||
| 8 | BM | Dx | t(11;14) | 1R0G3F (40%) | +‡ | MCL |
| 9 | BM | Dx | t(11;14) | 3R3G3F (38%) | +‡ | MCL |
| 10 | BM | Dx | t(11;14) | NE | ||
| BM | Rel (+63) | t(11;14) | 1R1G2F (72%), 2R2G3F (15%) | +‡ | MCL | |
| 11 | BM | Dx | t(11;14) | 1R1G2F (62%), 2R1G2F (22%) | +‡ | MCL |
| 12 | BM | Dx | t(11;14) | 1R1G2F (39%) | + | MCL |
| 13 | LN | Dx | t(11;14) | 2R2G | − | |
| LN | Dx | t(3;var) | 1R1G1F (17.6%) | + | FL | |
| 14 | LN | Rel (+178) | t(14;18) | 1R1G2F (53%) | + | FL |
| 15 | LN | Dx | t(14;18) | 1R1G2F (15%), 1R1G3F (12.4%), 2R2G3F (15.6%) | +‡ | FL |
| 16 | Salivary | Rel (+13) | t(14;18) | 2R2G | − | FL |
| Salivary | Rel (+13) | t(3;var) | 0R0G2F | − | ||
| 17 | LN | Dx | t(14;18) | 1R1G2F (44%) | + | FL |
| 18 | LN | Rel (+39) | t(14;18) | 1R1G2F (70%) | + | FL |
| 19 | LN | Dx | t(14;18) | 1R1G2F (30%), 1R1G1F (23%) | +‡ | FL |
| 20 | LN | Rel (+116) | t(14;18) | 1R1G2F (10.5%) | + | FL |
| 21 | LN | Dx | t(14;18) | 1R1G2F (29%), 1R1G1F (15%), 2R2G2F (10%) | +‡ | FL |
| 22 | Soft tissue | Dx | t(14;18) | 1R1G2F (71%), 0R0V2F (11%) | +‡ | FL |
| 23 | LN | Rel (+91) | t(14;18) | 1R1G2F (16%) | + | FL |
| 24 | LN | Dx | t(14;18) | 1R1G2F (13%) | + | FL |
| 25 | LN | Dx | t(14;18) | 1R1G2F (58%), 1R1G1F (23%) | +‡ | FL |
| 26 | LN | Dx | t(14;18) | 1R1G2F (37%) | + | FL |
| 27 | LN | Dx | t(11;14) | 2R3G (62%) | −‡ | |
| LN | Dx | t(14;18) | 1R1G2F (59.4%) | + | FL | |
| 28 | LN | Dx | t(11;14) | 2R3G (28%) | −‡ | |
| LN | Dx | t(14;18) | 1R1G2F (31%) | + | FL | |
| 29 | LN | Dx | t(14;18) | 2R2G2F (60%), 1R1G3F (11%) | +‡ | FL |
| 30 | Skin | Rel (+90) | t(14;18) | 1R1G2F (17%) | + | FL |
| 31 | LN | Dx | t(14;18) | 2R2G | − | |
| LN | Dx | t(3;var) | 1R1G1F (12.4%) | + | FL | |
| 32 | BM | Dx | t(14;18) | 1R1G2F (14%) | + | FL |
| 33 | BM | Dx | t(14;18) | 1R1G2F (75.6%) | + | FL |
| 34 | BM | Dx | t(14;18) | 2R2G | − | FL |
| BM | F-up (+7) | t(3;var) | 0R0G2F | − | ||
| 35 | LN | Dx | t(8;14) | 2A2R2G | − | DLBCL |
| LN | Dx | t(3;var) | 0R0G2F | − | ||
| BM | Dx | t(8;14) | 2A2R2G | − | ||
| BM | Dx | t(3;var) | 0R0G2F | − | ||
| 36 | Testicle | Rel (+41) | t(14;18) | 4R2G (26%) | −‡ | |
| Testicle | Rel (+41) | t(8;14) | 2A2R2G | − | ||
| Testicle | Rel (+41) | t(3;var) | 1R1G1F (26%) | + | DLBCL | |
| 37 | CNS | Dx | t(14;18) | 2R2G | − | |
| CNS | Dx | t(8;14) | 2A2R2G | − | ||
| CNS | Dx | t(3;var) | 1R1G2F (55%) | +‡ | DLBCL | |
| 38 | LN | Dx | t(14;18) | 2R2G | − | DLBCL |
| LN | Dx | t(11;14) | 2R2G | − | ||
| LN | Dx | t(3;var) | 0R0G2F | − | ||
| 39 | Ascites | Dx | t(14;18) | 4R4G (73%), 8R8G(8%) | −‡ | DLBCL |
| Ascites | Dx | t(8;14) | 4A4R4G (82%), 8A8R8G (3%) | −‡ | ||
| Ascites | Dx | t(3;var) | 0R0G2F | − | ||
| 40 | Ascites | Dx | t(14;18) | 3R3G (51%), 3R4G (11%) | −‡ | |
| Pleural fluid | Dx | t(14;18) | 1R1G1F (25%), 3R3G (13%), 2R3G (19%) | +‡ | DLBCL | |
| 41 | LN | Dx | t(8;14) | 2A2R2G | − | DLBCL (HIV) |
| 42 | Soft tissue | Dx | t(14;18) | 2R2G | − | MZL |
| 43 | BM | Rel (+22) | t(11;14) | 2R2G | − | MZL |
| 44 | BM | Dx | t(11;14) | 2R2G | − | B-CLL |
| 45 | Ascites | Rel (+85) | t(11;14) | 2R2G | − | B-CLL |
| 46 | BM | Dx | t(11;14) | 2R2G | − | B-CLL |