Mutations of BRAF and NRAS in various types of melanoma
| Site | Mean age (range) | Sample size | No. of mutated BRAF (%) | Nucleotide | Amino acid | No. of mutated NRAS (%) | Nucleotide | Amino acid |
|---|---|---|---|---|---|---|---|---|
| Mucosal melanoma | 68.1 (33–95) | 36 | 2 (5.6) | 5 (13.9) | ||||
| Head and neck | ||||||||
| Nasopharynx | 13 | 1 (7.7) | T1799A | V600E | 1 (7.7) | G34T | G12C | |
| Maxilla | 3 | 0 (0) | 0 (0) | |||||
| Hard palate or floor of mouth | 4 | 0 (0) | 1 (25) | A183C | Q61H | |||
| Female genital tract | ||||||||
| Cervix | 1 | 0 (0) | 0 (0) | |||||
| Vagina | 4 | 0 (0) | 1 (25) | C181A | Q61K | |||
| Vulva | 3 | 1 (33.3) | A1742T | N581I | 0 (0) | |||
| Gastrointestinal tract | ||||||||
| Oesophagus | 3 | 0 (0) | 2 (66.7) | G35A A183T | G12D Q61H | |||
| Rectum | 3 | 0 (0) | 0 (0) | |||||
| Anus | 2 | 0 (0) | 0 (0) | |||||
| Melanoma of parenchymal organs | ||||||||
| Brain | 23 | 1 | 0 (0) | 1 (100) | C181A | Q61K | ||
| Ovary | 48 | 1 | 0 (0) | 0 (0) | ||||
| Malignant melanoma of soft parts | 27.7 (17–38) | 7 | 0 (0) | 0 (0) | ||||
| Uveal melanoma | 61 (46–80) | 6 | 0 (0) | 1 (16.7) | A182G | Q61R | ||
| Cutaneous melanoma | 55.6 (40–79) | 5 | 2 (40) | T1799A GT1798–99AA | V600E V600K | 0 (0) |