Study group | TTV positive (UTR-PCR) | Genogroup 1 TTV positive (ORF-PCR) | HPV positive | Genogroup 1 TTV–HPV coinfection |
---|---|---|---|---|
*Metastasis or relapse. | ||||
HPV, human papillomavirus; ORF, open reading frame; PCR, polymerase chain reaction; TTV, transfusion transmitted virus; UTR, untranslated region. | ||||
Healthy individuals (n = 40) | 29 (72.5%) | 2 (5%) | 10 (25%) | 1 (2.5%) |
Laryngeal papillomatosis (n = 10) | 8 (80%) | 2 (20%) | 10 (100%) | 2 (20%) |
Papilloma with malignant transformation (n = 5) | 5 (100%) | 5 (100%) | 4 (80%) | 4 (80%) |
Squamous cell carcinoma (n = 25) | 22 (88%) | 11 (44%) | 12 (48%) | 8 (32%) |
Without tumour progression (n = 14) | 11 (78.6%) | 3 (21.4%) | 3 (21.4%) | 0 (0%) |
With tumour progression* (n = 11) | 11 (100%) | 8 (72.7%) | 9 (81.8%) | 8 (72.7%) |