Immunohistochemical profile of our case
| Marker | PDC | PAC | AA | AH |
|---|---|---|---|---|
| Staining intensity: +++, strong; +, weak; −, negative staining. | ||||
| *Positive only in peripheral lesions; †positive only in basal lesions; ‡positive only at the luminal surface and in glandular cells; §positive only at the luminal surface. | ||||
| αSMA, α smooth muscle antigen; AA, apocrine adenoma; AH, apocrine hyperplasia; CEA, carcinoembryonic antigen; EMA, epithelial membrane antigen; ER, oestrogen receptor; GCDFP-15, gross cystic disease fluid protein 15; PAC, papillary apocrine carcinoma; PDA, poorly differentiated carcinoma; PR, progesterone receptor. | ||||
| αSMA | − | − | +* | +++† |
| S-100 | − | − | +* | +++† |
| EMA | +++ | +++ | +++‡ | +++§ |
| GCDFP-15 | +++ | +++ | +++‡ | +++§ |
| Cytokeratin | +++ | +++ | +++ | + |
| PR | + | + | + | − |
| ER | − | − | − | − |
| HER-2 | − | − | − | − |
| Ki-67 | 12.5% | 6.4% | 3.8% | − |
| p53 | 46.4% | 63.6% | 54.4% | − |
| CEA | − | − | − | − |