Sample | HPV status | MCM5 staining score | ||||
---|---|---|---|---|---|---|
0 | 0a | 1 | 2 | 3 | ||
N refers to the number of cases tested. Not all cases included in our study were tested for HPV status. No case was found to be positive for HPV-31 or HPV-33. | ||||||
Staining score: 0, no positive staining of dysplastic cells; 0a, basal layer staining; 1, basal layer staining plus <10% positive staining of dysplastic cells; 2, >10% but <50% positive staining of dysplastic cells; 3, >50% positive staining of dysplastic cells. | ||||||
cGIN, cervical glandular intraepithelial neoplasia; hcGIN, high grade cervical glandular neoplasia; CIN, cervical intraepithelial neoplasia; HPV, human papillomavirus; SCC, squamous cell carcinoma. | ||||||
Normal (n = 20) | HPV− | 18/20 (90%) | ||||
HPV-6/11 | 2/20 (10%) | |||||
HPV-16 | ||||||
HPV-18 | ||||||
HPV unknown | ||||||
% Total | 100% | |||||
CIN1 (n = 31) | HPV− | 1/31 (3%) | 1/31 (3%) | 1/31 (3%) | 1/31 (3%) | |
HPV-6/11 | 1/31 (3%) | 2/23 (6.5%) | ||||
HPV-16 | 5/31 (16%) | 6/31 (19%) | 5/31 (17%) | |||
HPV-18 | ||||||
HPV unknown | 1/31 (3%) | 4/31 (13%) | 1/31 (3%) | 2/31 (6.5%) | ||
% Total | 6% | 32% | 28% | 33% | ||
CIN2 (n = 25) | HPV− | 1/25 (4%) | 1/25 (4%) | 1/25 (4%) | ||
HPV-6/11 | 2/25 (8%)) | |||||
HPV-16 | 1/25 (4%) | 8/25 (32%) | 5/25 (20%) | 3/25 (12%) | ||
HPV-18 | ||||||
HPV unknown | 2/25 (8%) | 1/25 (4%) | ||||
% Total | 4% | 44% | 36% | 16% | ||
CIN3 (n = 38) | HPV− | 1/38 (3%) | 1/38 (3%) | 1/38 (3%) | ||
HPV-6/11 | 1/38 (3%) | |||||
HPV-16 | 7/38 (17%) | 9/38 (24%) | 6/38 (15%) | |||
HPV-18 | 1/38 (3%) | 1/38 (3%) | ||||
HPV unknown | 2/38(5%) | 5/38 (13%) | 1/38 (3%) | 2/38 (5%) | ||
% Total | 8% | 36% | 33% | 23% | ||
SCC (n = 8) | HPV− | |||||
HPV-6/11 | ||||||
HPV-16 | 2/8 (25%) | 6/8 (75%) | ||||
HPV-18 | ||||||
HPV unknown | ||||||
% Total | 25% | 75% | ||||
cGIN (n = 5) | HPV unknown | 1/17 (6%) | 2/17 (12%) | 2/17(12%) | ||
hcGIN (n = 12) | HPV unknown | 2/17 (12%) | 2/17 (12%) | 8/17 (46%) | ||
% Total | 18% | 12% | 24% | 46% | ||
Adenocarcinoma (n = 10) | HPV unknown | 1/10 (10%) | 4/10 (40%) | 5/10 (50%) | ||
% Total | 10% | 40% | 50% |