Clinicopathological features and the expression of MUC4, ErbB2, p27, and MUC1 in 135 patients with invasive ductal carcinoma of the pancreas
| Category | N (%) | MUC4 | ErbB2 | p27 | MUC1 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Low expression* | High expression* | p Value | Low expression | High expression | p Value | Low expression | High expression | p Value | Low expression | High expression | p Value | ||
| The p values were assessed by means of the χ2 test. | |||||||||||||
| *Low expression, under 20% of neoplastic cells stained; high expression, more than 20% of neoplastic cells stained | |||||||||||||
| Age (years) | |||||||||||||
| ⩽65 | 51 (37.8) | 43 (84.3) | 8 (15.7) | 0.9740 | 41 (80.4) | 10 (19.6) | 0.8003 | 31 (60.8) | 20 (39.2) | 0.4888 | 16 (31.4) | 35 (68.6) | 0.6198 |
| >65 | 84 (62.2) | 71 (84.5) | 13 (15.5) | 66 (78.6) | 18 (21.4) | 56 (66.7) | 28 (33.3) | 23 (27.4) | 61 (72.6) | ||||
| Sex | |||||||||||||
| Male | 89 (65.9) | 75 (84.3) | 14 (15.7) | 0.9379 | 72 (80.9) | 17 (19.1) | 0.5134 | 60 (67.4) | 29 (32.6) | 0.3158 | 28 (31.5) | 61 (68.5) | 0.3591 |
| Female | 46 (34.1) | 39 (84.8) | 7 (15.2) | 35 (76.1) | 11 (23.9) | 27 (58.7) | 19 (41.3) | 11 (23.9) | 35 (76.1) | ||||
| Primary tumour | |||||||||||||
| ⩽T2 | 20 (14.8) | 19 (95.0) | 1 (5.0) | 0.1582 | 17 (85.0) | 3 (15.0) | 0.4927 | 16 (80.0) | 4 (20.0) | 0.1153 | 6 (30.0) | 14 (70.0) | 0.9054 |
| >T2 | 115 (85.2) | 95 (82.6) | 20 (17.4) | 90 (78.3) | 25 (21.7) | 71 (61.7) | 44 (38.3) | 33 (28.7) | 82 (71.3) | ||||
| Lymph node metastasis | |||||||||||||
| No | 59 (43.7) | 52 (88.1) | 7 (11.9) | 0.2971 | 43 (72.9) | 16 (27.1) | 0.1073 | 39 (66.1) | 20 (33.9) | 0.7230 | 19 (32.2) | 40 (67.8) | 0.4541 |
| Yes | 76 (56.3) | 62 (81.6) | 14 (18.4) | 64 (84.2) | 12 (15.8) | 48 (63.2) | 28 (36.8) | 20 (26.3) | 56 (73.7) | ||||
| Distant metastasis | |||||||||||||
| No | 128 (94.8) | 108 (84.4) | 20 (15.6) | 0.9242 | 101 (78.9) | 27 (21.1) | 0.6653 | 83 (64.8) | 45 (35.2) | 0.6785 | 39 (30.5) | 89 (69.5) | 0.0833 |
| Yes | 7 (5.2) | 6 (85.7) | 1 (14.3) | 6 (85.7) | 1 (14.3) | 4 (57.1) | 3 (42.9) | 0 (0.0) | 7 (100.0) | ||||
| Histological grade | |||||||||||||
| G1 | 37 (27.4) | 32 (86.5) | 5 (13.5) | 0.7762 | 24 (64.9) | 13 (35.1) | 0.0234 | 27 (73.0) | 10 (27.0) | 0.2388 | 15 (40.5) | 22 (59.5) | 0.1171 |
| G2 | 73 (54.1) | 62 (84.9) | 11 (15.1) | 60 (82.2) | 13 (17.8) | 47 (64.4) | 26 (35.6) | 16 (21.9) | 57 (78.1) | ||||
| G3 | 25 (18.5) | 20 (80.0) | 5 (20.0) | 23 (92.0) | 2 (8.0) | 13 (52.0) | 12 (48.0) | 8 (32.0) | 17 (68.0) | ||||
| Lymphatic invasion | |||||||||||||
| No | 9 (6.7) | 9 (100.0) | 0 (0.0) | 0.1826 | 6 (66.7) | 3 (33.3) | 0.3348 | 8 (88.9) | 1 (11.1) | 0.1128 | 4 (44.4) | 5 (55.6) | 0.2865 |
| Yes | 126 (93.3) | 105 (83.3) | 21 (16.7) | 101 (80.2) | 25 (19.8) | 79 (62.7) | 47 (37.3) | 35 (27.8) | 91 (72.2) | ||||
| Venous invasion | |||||||||||||
| No | 35 (25.9) | 31 (88.6) | 4 (11.4) | 0.4338 | 28 (80.0) | 7 (20.0) | 0.9001 | 23 (65.7) | 12 (34.3) | 0.8553 | 8 (22.9) | 27 (77.1) | 0.3603 |
| Yes | 100 (74.1) | 83 (83.0) | 17 (17.0) | 79 (79.0) | 21 (21.0) | 64 (64.0) | 36 (36.0) | 31 (31.0) | 69 (69.0) | ||||
| Perineural invasion | |||||||||||||
| No | 13 (9.6) | 12 (92.3) | 1 (7.7) | 0.4106 | 13 (100.0) | 0 (0.0) | 0.0524 | 10 (76.9) | 3 (23.1) | 0.3228 | 5 (38.5) | 8 (61.5) | 0.4231 |
| Yes | 122 (90.4) | 102 (83.6) | 20 (16.4) | 94 (77.0) | 28 (23.0) | 77 (63.1) | 45 (36.9) | 34 (27.9) | 88 (72.1) | ||||
| Surgical margins | |||||||||||||
| Negative | 78 (57.8) | 66 (84.6) | 12 (15.4) | 0.9489 | 62 (79.5) | 16 (20.5) | 0.9391 | 52 (66.7) | 26 (33.3) | 0.5281 | 22 (28.2) | 56 (71.8) | 0.8375 |
| Positive | 57 (42.2) | 48 (84.2) | 9 (15.8) | 45 (78.9) | 12 (21.1) | 35 (61.4) | 22 (38.6) | 17 (29.8) | 40 (70.2) | ||||