Gene | Chromosomal locus | Putative function | Status in prostate cancer |
---|---|---|---|
ELAC2 | 17p | Metal dependent hydrolase | Unknown |
RNASEL | 1q | Ribonuclease that degrades viral and cellular RNA and can produce >apoptosis on viral infection | Deleted |
MSR1 | 8p | Encodes a macrophage scavenger receptor responsible for cellular >uptake of molecules, including bacterial cell wall products | Deleted |
NBSI | 5p | Encodes a protein, nibrin, involved in the processing/repair of DNA >double strand breaks and in cell cycle checkpoints | Deleted |
CHEK2 | 22q | Upstream regulator of p53 in the DNA damage signalling pathway | Deleted |