Table 1
Frequent molecular abnormalities in head and neck squamous cell carcinoma
LOH 9p
70–80%
LOH 3p
60–70%
LOH 17p
50–70%
LOH 11q
30%
LOH 13q
30%
Inactivation of p16
ink4A
(homozygous deletion, promoter methylation, point mutation)
80%
Inactivation of
FHIT
and
RASSF1A
p53 mutation
50–80%
Cyclin D1 amplification
30%