Table 1

 Frequent molecular abnormalities in head and neck squamous cell carcinoma

LOH 9p70–80%
LOH 3p60–70%
LOH 17p50–70%
LOH 11q30%
LOH 13q30%
Inactivation of p16ink4A (homozygous deletion, promoter methylation, point mutation)80%
Inactivation of FHIT and RASSF1A p53 mutation50–80%
Cyclin D1 amplification30%