kit
| 11 | 20–60 | Deletion–insertion 550–561 | Deletion is often associated with bad prognosis. Good response to imatinib |
Point mutations 557, 559, 560, 576 |
Internal tandem duplications beyond 570 (3′ end) |
9 | 10–15 | Duplication–insertion 501–502 | Malignant behaviour Small intestine Intermediate response to imatinib |
13 | <5 | Point mutation 642 | Bad response to imatinib |
17 | Rare (<1) | Point mutation 820 | Bad response to imatinib |
pdgfra
| 12 | Roughly 1 | Point mutation 561 | Good response to imatinib |
Deletion–insertion 560–571 |
Insertion 582–586 |
14 | <0.5 | Point mutation 659 | |
18 | 2–3 | Point mutation 842 | Mutation 842 (D842V) resistant to imatinib Other sensitive |
Deletion–substitution 842–847 |