Antibody | SPT | PET | ACC | RCC | MM |
CD56 | Focally positive in up to 100% | Positive in 25–50% | Positive | Positive | Positive |
CD10 | Positive in 80% | Positive in up to 10% | Positive | Positive | Positive |
PR | Positive | Positive | Positive | Negative | Positive |
Synaptophysin | Positive in up to 70% | Positive 100% | Positive | Negative | Negative |
β-Catenin | Nuclear/cytopositivity 100% | Nuclear/cytopositivity in rare cases | ? | ? | ? |
E-cadherin | Nuclear* 100% | Nuclear* 30% | ? | Nuclear* 50%—clear cell variant only | Nuclear not described |
Loss of membrane staining 100% | Retention of membrane staining 95–100% | Retention of membrane staining in majority | Occasional membrane loss |
*Nuclear immunoreactivity with the antibody to the cytoplasmic domain of E-cadherin.
ACC, acinar cell carcinoma; cyto, cytoplasmic; MM, malignant melanoma; PET, pancreatic endocrine tumour; RCC, renal cell carcinoma.