Table 1 Common immunohistochemical panel of antibodies for solid pseudopapillary tumour (SPT) and its mimics
AntibodySPTPETACCRCCMM
CD56Focally positive in up to 100%Positive in 25–50%PositivePositivePositive
CD10Positive in 80%Positive in up to 10%PositivePositivePositive
PRPositivePositivePositiveNegativePositive
SynaptophysinPositive in up to 70%Positive 100%PositiveNegativeNegative
β-CateninNuclear/cytopositivity 100%Nuclear/cytopositivity in rare cases???
E-cadherinNuclear* 100%Nuclear* 30%?Nuclear* 50%—clear cell variant onlyNuclear not described
Loss of membrane staining 100%Retention of membrane staining 95–100%Retention of membrane staining in majorityOccasional membrane loss
  • *Nuclear immunoreactivity with the antibody to the cytoplasmic domain of E-cadherin.

  • ACC, acinar cell carcinoma; cyto, cytoplasmic; MM, malignant melanoma; PET, pancreatic endocrine tumour; RCC, renal cell carcinoma.