Table 1 Clinical and pathological features to consider before diagnosing inflammatory myofibroblastic tumour (IMT)
Features that favour IMTFeatures that argue against IMT
Child or young adultMiddle-aged or older adult
Mass in lung or soft tissue of abdomen, pelvis, or retroperitoneumMass in skin or subcutis, lymph node, spleen, or bladder
Diffuse inflammatory infiltrate with prominent plasma cellsPatchy, predominantly lymphocytic inflammatory infiltrate
Mild nuclear atypia including scattered ganglion-like cellsModerate to severe nuclear atypia with hyperchromasia
Low mitotic rate without atypical formsAtypical mitoses
ALK positivity by immunohistochemistry or ALK gene rearrangementNecrosis