(A) Most recurrent chromosomal alterations in PLB (losses and gains are separated) | |||||||
Chromosome band | Start clone | End clone | Start position (bp) | End position (bp) | Size (bp) | CNA | No of cases |
1p36.3–1p35.1 | RP4-785P20 | RP1-117N3 | 3214521 | 33379650 | 30165129 | Loss | 5 |
6q14.1–6q27 | RP11-25O6 | RP5-1086L22 | 83405494 | 170509779 | 87104285 | Loss | 4 |
14q32.33 | RP11-417P24 | CTC-820M16 | 105267358 | 106278173 | 1010815 | Loss | 7 |
15q11.2–15q26.5 | RP11-289D12 | RP11-14C10 | 20363717 | 100036184 | 79672467 | Loss | 5 |
1q21.1–1q44.1 | RP3-365I19 | RP11-438H8 | 142642781 | 247249719 | 104606938 | Gain | 5 |
2p16.1–2p15 | RP11-440P5 | RP11-479F13 | 60501800 | 61422449 | 20349 | Amplification | 4 |
6p21.31 | RP11-175A4 | RP1-90K10 | 33521322 | 37077773 | 3556451 | Gain | 4 |
7p22–7q36.2 | RP11-449P15 | RP11-518I12 | 885103 | 157752947 | 156867844 | Gain | 6 |
(B) Candidate genes residing in frequently altered regions | |||||
Chromosome | Chromosome band | Size (bp) | CNA | No of cases | Cancer gene census |
1 | 1p36.3–1p35.1 | 30165129 | Loss | 5 | LCK, MDS2, SDHB, PRDM16, PAX7 |
14 | 14q32.33 | 1010815 | Loss | 7 | IGH |
2 | 2p16.1–2p15 | 920349 | Amplification | 4 | REL, BCL11A |
6 | 6p21.31 | 3556451 | Gain | 4 | HMGA1, SFRS3, FANCE |
CNA, copy number alteration.