Table 1

Application of Bayes' rule to the use of clinical symptoms as a diagnostic test for variegate porphyria in a European population

Disease prevalence in the population0.000007
Sensitivity of clinical symptoms as a diagnostic tool0.4 (40%)
Specificity of clinical symptoms as a diagnostic tool0.5 (50%)
Probability that a positive test is a true positive0.00056%
Probability that a positive test is a false positive99.99944%