Feature | IBD>infective | Infective>IBD | UC>CD | CD>UC |
---|---|---|---|---|
Architecture | ||||
Preserved architecture | + + + | + | ||
Crypt distortion | + + + | + + | ||
Crypt atrophy | + + + | + + | ||
Diffuse intersite or intrasite crypt changes (in IBD) | + + + | |||
Non-diffuse crypt changes (in IBD) | + | |||
Irregular mucosal surface | + + + | + + | ||
Inflammation | ||||
Basal plasmacytosis | + + + | |||
Lymphoid aggregates | + + | |||
Diffuse intersite or intrasite CI (in IBD) | + + + | |||
Non-diffuse/focal CI (in IBD) | + + | |||
Inflammation upper LP | + | |||
Granulomas (non-cryptolytic) | + + | + + + + | ||
LP acute inflammation (no CI) | + | |||
Widespread cryptitis (in IBD) | + | |||
Other changes | ||||
Mucin depletion | + + | |||
Paneth cell metaplasia | + | |||
Ileal inflammation (in IBD) | + + |
+ + + +, very strongly discriminant; + + +, highly discriminant; + +, moderately discriminant; +, weakly discriminant; CD: Crohn's disease; CI: chronic inflammation; IBD, inflammatory bowel disease; LP: lamina propria; UC: ulcerative colitis.