Table 10

Time-related changes in untreated IBD

Time	Histological feature (% of cases)					References
Duration of symptoms	Basal plasma cells	Crypt distortion	Crypt atrophy	Villous surface	Granuloma
1–15 days	38	0	0	0		4
16–30 days	54	23	31	23		4
31–120 days	81	20	43	33		4
121–300 days	89	78	44	33		4
<25 days					0	18

IBD, inflammatory bowel disease.