Feature | Rate (%) | Survival | Univariate analysis | Multivariate analysis | |||||
---|---|---|---|---|---|---|---|---|---|
95% CI | p Value* | RR | 95% CI | p Value | RR | 95% CI | p Value | ||
Ki67 | |||||||||
<10 | 97.1 | 93.2 to 100 | <0.001 | 1 | 1 | ||||
≥10 | 77.6 | 70.2 to 85.0 | 8.88 | 2.11 to 37.35 | 0.003 | 7.96 | 1.69 to 37.48 | 0.009 | |
Age† | |||||||||
<35 | 66.7 | 40.0 to 93.4 | 0.051 | 2.72 | 0.95 to 7.82 | 0.063 | 1.59 | 0.52 to 4.84 | 0.414 |
≥35 | 86.1 | 81.2 to 91.0 | 1 | 1 | |||||
Tumour size | |||||||||
≤10 | 94.1 | 86.3 to 100 | 1 | 1 | |||||
11–15 | 89.3 | 81.9 to 96.7 | 0.444 | 1.78 | 0.37 to 8.58 | 0.471 | 0.79 | 0.16 to 4.03 | 0.778 |
16–20 | 82.8 | 72.6 to 93.0 | 0.136 | 3.04 | 0.66 to 14.09 | 0.155 | 1.39 | 0.28 to 6.96 | 0.689 |
>20 | 73.7 | 61.0 to 86.4 | 0.02 | 4.35 | 096 to 19.63 | 0.056 | 1.73 | 0.32 to 9.30 | 0.521 |
Histological grade | |||||||||
1 | 89.2 | 81.8 to 96.6 | 1 | 1 | |||||
2 | 87.1 | 79.3 to 94.9 | 0.659 | 1.5 | 0.53 to 4.20 | 0.446 | 0.81 | 0.27 to 2.39 | 0.699 |
3 | 77.8 | 67.6 to 88.0 | 0.055 | 2.72 | 1.05 to 7.08 | 0.04 | 1.11 | 0.27 to 4.52 | 0.887 |
Oestrogen receptor status | |||||||||
Positive | 86.6 | 81.1 to 92.1 | 0.125 | 0.54 | 0.25 to 1.19 | 0 .126 | 0.96 | 0.33 to 2.81 | 0.934 |
Negative | 78.6 | 66.3 to 90.9 | 1 | 1 | |||||
LVI | |||||||||
No | 89.8 | 84.9 to 94.7 | 0.001 | 1 | 1 | ||||
Yes‡ | 70.5 | 57.6 to 83.4 | 3.17 | 1.51 to 6.66 | 0.002 | 2.77 | 1.26 to 6.11 | 0.012 | |
Mitotic index§ | |||||||||
<10 | 87.8 | 82.1 to 93.5 | 0.076 | 1 | 1 | ||||
≥10 | 79.1 | 69.3 to 88.9 | 1.95 | 0.94 to 4.04 | 0.072 | 0.6 | 0.18 to 1.98 | 0.4 | |
CK5/6 | |||||||||
Negative | 87.2 | 81.5 to 92.9 | 0.186 | 1 | 1 | ||||
Positive | 79.7 | 69.5 to 89.9 | 1.62 | 0.77 to 3.38 | 0.203 | 1.23 | 0.55 to 2.76 | 0.622 | |
HER2 | |||||||||
Negative | 84.8 | 79.5 to 90.1 | 0.583 | 1 | 0.588 | ||||
Positive | 91.7 | 76.0 to 100 | 0.58 | 0.08 to 4.24 | |||||
Contralateral | |||||||||
Yes | 72.7 | 46.4 to 99.0 | 0.198 | 2.13 | 0.65 to 7.05 | 0.214 | |||
No | 85.6 | 80.5 to 90.7 | 1 |
*p Value is for comparison of each category with the reference category. The number in each category is shown in table 2.
†Age at diagnosis in years.
‡Includes three indeterminate cases.
§Mitotic count per 10 high powered fields (0.55 mm field diameter).
CK, cytokeratin; HER2, human epidermal growth factor 2; LVI, lymphovascular invasion.