Risk of death from breast cancer according to TOP2A and HER2 amplification
| Number of cases | Deaths from breast cancer | Hazard ratio 95% CI unadjusted | Hazard ratio 95% CI adjusted for age | Hazard ratio 95% CI adjusted for stage | ||||
|---|---|---|---|---|---|---|---|---|
| TOP2A | ||||||||
| Follow-up first 5 years after diagnosis | 604 | 132 | 1.00 | 1.00 | 1.00 | |||
| Not amplified | 41 | 17 | 2.03 | 1.22 to 3.36 | 2.07 | 1.24 to 3.47 | 2.11 | 1.27 to 3.50 |
| Amplified | 25 | 5 | 0.91 | 0.37 to 2.21 | 0.82 | 0.33 to 2.01 | 0.70 | 0.29 to 1.73 |
| Loss | 670 | 154 | ||||||
| TOP2A | ||||||||
| Follow-up from 5 years after diagnosis* | 359 | 87 | 1.00 | 1.00 | 1.00 | |||
| Not amplified | 22 | 5 | 0.75 | 0.30 to 1.85 | 0.74 | 0.30 to 1.86 | 1.02 | 0.41 to 2.54 |
| Amplified | 15 | 5 | 1.63 | 0.66 to 4.03 | 1.93 | 0.77 to 4.84 | 1.41 | 0.56 to 3.52 |
| Loss | 396 | 97 | ||||||
| HER2 | ||||||||
| Follow-up first 5 years after diagnosis | 560 | 105 | 1.00 | 1.00 | 1.00 | |||
| Not amplified | 110 | 49 | 2.77 | 1.97 to 3.89 | 2.81 | 1.95 to 4.04 | 2.66 | 1.89 to 3.75 |
| Amplified | 670 | 154 | ||||||
| HER2 | ||||||||
| Follow-up from 5 years after diagnosis* | 346 | 83 | 1.00 | 1.00 | 1.00 | |||
| Not amplified | 50 | 14 | 0.95 | 0.54 to 1.67 | 0.95 | 0.52 to 1.73 | 1.04 | 0.60 to 1.86 |
| Amplified | 396 | 97 | ||||||
| HER2 and TOP2A | ||||||||
| Follow-up first 5 years after diagnosis | 532 | 100 | 1.00 | 1.00 | 1.00 | |||
| Normal TOP2A and HER2 | 38 | 17 | 2.61 | 1.56 to 4.36 | 2.76 | 1.63 to 4.69 | 2.68 | 1.60 to 4.51 |
| TOP2A change and HER2 amplification | 28 | 5 | 0.96 | 0.39 to 2.37 | 0.89 | 0.36 to 2.21 | 0.77 | 0.31 to 1.90 |
| TOP2A change and HER2 normal | 72 | 32 | 2.86 | 1.92 to 4.26 | 2.81 | 1.84 to 4.29 | 2.59 | 1.74 to 3.87 |
| Amplified HER2, TOP2A normal | 670 | 154 | ||||||
| HER2 and TOP2A | ||||||||
| Follow-up from 5 years after diagnosis* | 328 | 79 | 1.00 | 1.00 | 1.00 | |||
| Normal TOP2A and HER2 | 19 | 6 | 0.99 | 0.43 to 2.28 | 0.97 | 0.41 to 2.28 | 1.44 | 0.62 to 3.37 |
| TOP2A change and HER2 amplification | 18 | 4 | 1.07 | 0.39 to 2.94 | 1.26 | 0.45 to 3.50 | 0.91 | 0.33 to 2.51 |
| TOP2A change and HER2 normal | 31 | 8 | 0.92 | 0.45 to 1.91 | 0.95 | 0.44 to 2.04 | 0.84 | 0.40 to 1.79 |
| Amplified HER2, TOP2A normal | 396 | 97 | ||||||
*Conditional on surviving the first 5 years CI.