Antibodies to free light chains | |
---|---|
Deposition | No deposition |
29 | 17 |
Abnormality/no abnormality | Abnormality/no abnormality |
28/1* | 4†/13 |
Sensitivity 88%, specificity 93% |
Conventional antibodies to light chains | |
---|---|
Deposition | No deposition |
20 | 26 |
Abnormality/no abnormality | Abnormality/no abnormality |
20/0 | 12‡/14 |
Sensitivity 63%, specificity 100% |
Difference in sensitivity (free light chain antibodies – conventional antibodies)=25% (95% CI 9% to 41%); difference in specificity (free light chain antibodies – conventional antibodies)=−7% (95% CI −14% to 0%).
*κ & AA deposition in AA amyloid.
†No deposition in AL amyloid (2), neoplastic infiltration (2).
‡No deposition in AL amyloid (8), cryoglobulinaemic glomerulonephritis (2), light chain deposition disease (1), neoplastic infiltration (1).