Tumours showing neuroendocrine differentiation by immunohistochemistry with chromogranin A and/or synaptophysin antibodies according to intensity and percentage of staining
| Antibodies | Chromogranin A | Synaptophysine | p Value* | |||
|---|---|---|---|---|---|---|
| Tumour type | n | Intensity† | Percentage | Intensity | Percentage | |
| ITACs | 1 | 3+ | 1 | 1+ | <1 | |
| 2 | 3+ | 15 | 1+ | 1 | ||
| 18/25 (72%) | 3 | 3+ | 5 | 1+ | <1 | |
| 4 | 3+ | 5 | 0 | 0 | ||
| 5 | 2+ | 10 | 1+ | 2 | ||
| 6 | 3+ | <1 | 1+ | <1 | ||
| 7 | 3+ | 1 | 1+ | 1 | ||
| 8 | 3+ | 1 | 0 | 0 | ||
| 9 | 3+ | <1 | 0 | 0 | ||
| 10 | 3+ | 10 | 2+ | 2 | ||
| 11 | 3+ | 1 | 1+ | <1 | ||
| 12 | 3+ | 1 | 0 | 0 | ||
| 13 | 3+ | <1 | 1+ | <1 | ||
| 14 | 3+ | 1 | 1+ | 1 | ||
| 15 | 2+ | 1 | 1+ | 1 | ||
| 16 | 3+ | 1 | 1+ | <1 | ||
| 17 | 1+ | <1 | 1+ | <1 | ||
| 18 | 3+ | 1 | 1+ | <1 | ||
| 0.0002 | ||||||
| nmCRAs | 1 | 2+ | <1 | 0 | 0 | |
| 2 | 0 | 0 | 1+ | 90 | ||
| 5/25 (20%) | 3 | 3+ | 10 | 1+ | 5 | |
| 4 | 1+ | 1 | 0 | 0 | ||
| 5 | 0 | 0 | 2+ | <1 | ||
*Neuroendocrine differentiation with chromogranin and/or synaptophysin staining was strongly associated to ITAC in comparison with nmCRAs by Fisher's exact test (p=0.0002).
†Negative (0), weakly (1+), moderately (2+) and strongly (3+) staining.
ITACs, intestinal-type adenocarcinomas; nmCRAs, node metastasis of CRA; n, list of cases.