Features of most common germ-line aberrations of young-age prostate cancer
| BRCA1 | BRCA2 | HOXB13 | |
|---|---|---|---|
| Genomic location | 17q21 | 13q12.3 | 17q21–22 |
| Relative risk of prostate cancer | 1.8–4.5 for age <65 years | 23 for age <55 years 2.5–8.6 for age <65 years | Eightfold for age <55 years |
| Ethnic predominance | Ashkenazi Jewish, Norwegian, Dutch and Icelandic people | Ashkenazi Jewish, Norwegian, Dutch and Icelandic people | Finnish, Swedish |
| Specific mutation associated with young-age prostate cancer | – | BRCA2 999del5 (Icelandic founder mutation) | HOXB13 G84E, rs138213197 |
| Characteristic histological features | – | Intraductal carcinoma in 42% | Pseudohyperplastic features in 45% |
| Prognosis | Unfavourable | Unfavourable | Favourable |
| Other associated cancers | Breast and ovary | Breast and ovary | Breast |