Twenty-nine most frequently altered genes in 98 cases of SCLC
| Gene | Predicted to be actionable | Substitution/indel | Amp | Deletion | Truncation | Fusion/rearrangement | Number of samples | Percentage of samples (%) |
|---|---|---|---|---|---|---|---|---|
| TP53 | No | 46 | 0 | 3 | 35 | 0 | 84 | 86 |
| RB1 | No | 2 | 0 | 12 | 39 | 0 | 53 | 54 |
| MLL2 | No | 1 | 0 | 0 | 16 | 0 | 17 | 17 |
| RICTOR | Yes | 0 | 10 | 0 | 0 | 0 | 10 | 10 |
| MYCL1 | No | 0 | 8 | 0 | 0 | 0 | 8 | 8 |
| FGF10 | No | 0 | 8 | 0 | 0 | 0 | 8 | 8 |
| LRP1B | No | 0 | 0 | 0 | 7 | 0 | 7 | 7 |
| KIT | Yes | 3 | 2 | 0 | 2 | 0 | 7 | 7 |
| PIK3CA | Yes | 3 | 3 | 0 | 0 | 0 | 6 | 6 |
| PTEN | Yes | 1 | 0 | 2 | 2 | 0 | 5 | 5 |
| MYST3 | No | 0 | 5 | 0 | 0 | 0 | 5 | 5 |
| KRAS | Yes | 4 | 1 | 0 | 0 | 0 | 5 | 5 |
| EGFR | Yes | 5 | 0 | 0 | 0 | 0 | 5 | 5 |
| ZNF703 | No | 0 | 4 | 0 | 0 | 0 | 4 | 4 |
| SPEN | No | 0 | 0 | 0 | 4 | 0 | 4 | 4 |
| SOX2 | No | 0 | 4 | 0 | 0 | 0 | 4 | 4 |
| MYC | No | 0 | 4 | 0 | 0 | 0 | 4 | 4 |
| MCL1 | Yes | 0 | 4 | 0 | 0 | 0 | 4 | 4 |
| FGFR1 | Yes | 0 | 4 | 0 | 0 | 0 | 4 | 4 |
| BRCA2 | Yes | 0 | 0 | 0 | 4 | 0 | 4 | 4 |
| TSC1 | Yes | 0 | 0 | 1 | 2 | 0 | 3 | 3 |
| NOTCH3 | No | 0 | 0 | 0 | 3 | 0 | 3 | 3 |
| NKX2-1 | No | 0 | 3 | 0 | 0 | 0 | 3 | 3 |
| NF1 | Yes | 0 | 0 | 1 | 2 | 0 | 3 | 3 |
| KDM6A | No | 0 | 0 | 0 | 3 | 0 | 3 | 3 |
| EPHA3 | Yes | 0 | 3 | 0 | 0 | 0 | 3 | 3 |
| CSF1R | No | 3 | 0 | 0 | 0 | 0 | 3 | 3 |
| CREBBP | No | 2 | 0 | 0 | 1 | 0 | 3 | 3 |
| CCND1 | Yes | 0 | 3 | 0 | 0 | 0 | 3 | 3 |
SCLC, Small cell lung cancer.