Light chain immunohistological findings in 41 renal biopsies containing amyloid
| AL amyloid | AA amyloid | Other amyloid | |
|---|---|---|---|
| Final diagnosis | 28 (23 λ, 5 κ) | 10 | 3 |
| Free light chain antibodies n=41 | 21 λ+ve, 2 λ −ve, 4 κ+ve, 1 κ & AA+ve (25/28 (89%) unambiguously diagnostic) | 9 −ve, 1 κ & AA+ve | 3 −ve |
| Conventional light chain antibodies n=32 | 14 λ+ve, 5 λ −ve, 1 κ+ve, 2 κ –ve (15/22 (68%) diagnostic) | 7 −ve | 3 −ve |
For AL amyloid, difference in proportion unambiguously diagnostic (antibodies to free light chains – conventional antibodies to light chains)=21% (95% CI 2% to 39%).