Clinical studies of lactobacilli showing efficacy for treatment of diarrhoea
| Bacteria | Dose | Pathology | Ref. (Design) |
|---|---|---|---|
| Actimel® (L. casei DN 114001) | 1010 CFU/100 mL | Antibiotic-associated diarrhoea | 249(observational study) |
| Balance (L. casei, L. rhamnosus, L. acidophilus, L. bulgaricus, B. strains B. breve, B. longum, St. thermophilus) | 1×108 CFU (total) | H. pylori infection-associated diarrhoea | 250(randomised placebo-controlled triple-blind study) |
| L. acidophilus L.rhamnosus B. bifidum, B. longum, E. faecium + fructo-oligosaccharide | 2.5×109 CFU (total) 625 mg | Acute diarrhoea | 251(prospective randomised, multicentre single-blinded clinical study) |
| L. acidophilus CUL60 (NCIMB 30157), CUL21 (NCIMB 30156), B. bifidum; CUL20, NCIMB 30153), B. lactis (CUL34, NCIMB 30172) | 6×1010 CFU (total) | Antibiotic-associated diarrhoea | 252(prospective, parallel group study) |
| Probiotical (S. thermophilus, L. rhamnosus, L. acidophilus, B. lactis, B. infantis + Fructooligosaccharides + Ascorbic ac | 6.5×109 CFU (60 mg) 6.5×109 CFU (28 mg) 6.5×109 CFU (28 mg) 6.5×109 CFU (20 mg) 6.5×109 CFU (20 mg) 20 mg 1.2 mg | Acute gastroenteritis | 253(randomised, prospective placebo-controlled parallel clinical study) |
| NAN 1® (L. acidophilus, L. rhamnosus, B. longum S. boulardii) | 6.625×107 CFU 3.625×107 CFU 8.75×106 CFU 1.375×107 CFU | Acute rotavirus diarrhoea | 254(prospective, double-blind, randomised study) |
| L. rhamnosus 35 | 6×108 CFU | Acute rotaviral gastroenteritis | 255(open-label randomised study) |
| L. rhamnosus (strains E/N, Oxy and Pen) | 2×1010 CFU (of each) | Antibiotic-associated diarrhoea | 256(double-blind, randomised, placebo-controlled study) |
| L. acidophilus LB + spent culture medium | 109 CFU 160 mg | Non-rotavirus diarrhoea | 257(randomised, double-blind, placebo-controlled clinical study) |
| Lakcid® L (L. rhamnosus (573 L/1; 573 L/2; 573 L/3)) | 1.2×1010 CFU (total) | Infectious diarrhoea | 258(randomised, double-blind, placebo-controlled study) |
| L. paracasei ST11 | 1010 CFU | Non-rotavirus diarrhoea | 259(randomised, double-blind, placebo-controlled clinical study) |
| L. casei CERELA, L. acidophilus CERELA, S. boulardii | 1011 CFU/g in 175 g (of each) | Persistent diarrhoea | 260(double-blind study) |
| L. rhamnosus 19070–2 L. reuteri DSM 12246 | 1010 CFU (of each) | Acute diarrhoea | 261(randomised placebo-controlled study) |
| L. casei CERELA, L. acidophillus CERELA | N/A | Bacterial overgrowth-related chronic diarrhoea | 262(randomised, double-blind study) |
| L. reuteri | 1010–11 CFU/g in 1 g | Acute diarrhoea | 263(randomised, placebo-controlled study) |