Associations between different categories of vascular invasion by immunohistochemistry and various clinicopathological variables (n=282, except for nodal status, n=281)
| BVI | LVI | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Variable | No. | 0 | >0 | OR | p Value | ≤1 | >1 | OR | p Value |
| Histological type | |||||||||
| Others | 54 | 51 (21%) | 3 (7%) | 1 | NS | 45 (21%) | 9 (13%) | 1 | NS |
| Ductal | 228 | 188 (79%) | 40 (93%) | 3.6 (1.1–12.2) | 167 (79%) | 61 (87%) | 1.8 (0.8–4.0) | ||
| Tumour size | |||||||||
| <2 cm | 214 | 189 (79%) | 25 (58%) | 1 | 0.003 | 164 (77%) | 50 (71%) | 1 | NS |
| ≥2 cm | 68 | 50 (21%) | 18 (42%) | 2.7 (1.4–5.4) | 48 (23%) | 20 (29%) | 1.4 (0.7–2.5) | ||
| Histological grade | |||||||||
| 1 | 76 | 73 (30%) | 3 (7%) | 1 | 0.001 | 66 (31%) | 10 (14%) | 1 | 0.006 |
| 2–3 | 206 | 166 (70%) | 40 (93%) | 5.9 (1.8–19.6) | 146 (69%) | 60 (86%) | 2.7 (1.3–5.6) | ||
| Nodal status* | |||||||||
| Negative | 187 | 167 (70%) | 20 (47%) | 1 | 0.002 | 151 (72%) | 36 (51%) | 1 | 0.002 |
| Positive | 94 | 71 (30%) | 23 (53%) | 2.7 (1.4–5.2) | 60 (28%) | 34 (49%) | 2.4 (1.4–4.1) | ||
| Oestrogen receptor | |||||||||
| Positive | 249 | 219 (92%) | 30 (70%) | 1 | <0.001 | 196 (92%) | 53 (76%) | 1 | <0.001 |
| Negative | 33 | 20 (8%) | 13 (30%) | 4.3 (2.0–9.4) | 16 (8%) | 17 (24%) | 3.9 (1.9–8.3) | ||
| PR | |||||||||
| Positive | 186 | 162 (68%) | 24 (56%) | 1 | NS | 152 (72%) | 34 (49%) | 1 | <0.001 |
| Negative | 96 | 77 (32%) | 19 (44%) | 1.7 (0.9–3.2) | 60 (28%) | 36 (51%) | 2.7 (1.5–4.7) | ||
| HER 2 status | |||||||||
| Negative | 255 | 226 (95%) | 29 (67%) | 1 | <0.001 | 199 (94%) | 56 (80%) | 1 | 0.001 |
| Positive | 27 | 13 (5%) | 14 (33%) | 8.4 (3.6–19.6) | 13 (6%) | 14 (20%) | 3.8 (1.7–8.6) | ||
| Ki67 | |||||||||
| Low | 211 | 191 (80%) | 20 (46%) | 1 | <0.001 | 168 (79%) | 43 (61%) | 1 | 0.003 |
| High | 71 | 48 (20%) | 23 (54%) | 4.6 (2.3–9.0) | 44 (21%) | 27 (39%) | 2.4 (1.3–4.3) | ||
| Triple-negative | |||||||||
| No | 261 | 223 (85%) | 38 (15%) | 1 | NS | 199 (76%) | 62 (24%) | 1 | NS |
| Yes | 21 | 16 (76%) | 5 (24%) | 1.8 (0.6–5.3) | 13 (62%) | 8 (38%) | 2.0 (0.8–5.0) | ||
| Basal-like | |||||||||
| Negative | 229 | 204 (89%) | 25 (11%) | 1 | <0.001 | 182 (80%) | 47 (20%) | 1 | 0.001 |
| Positive | 53 | 35 (66%) | 18 (34%) | 4.2 (2.1–8.5) | 30 (57%) | 23 (43%) | 3.0 (1.6–5.6) | ||
| Detection mode | |||||||||
| Screening | 200 | 185 (92%) | 15 (8%) | 1 | <0.001 | 158 (79%) | 42 (21%) | 1 | 0.020 |
| Interval | 82 | 54 (66%) | 28 (34%) | 6.4 (3.2–12.8) | 54 (66%) | 28 (34%) | 1.9 (1.1–3.4) | ||
p Values were obtained using Pearson's χ2 test.
*One case excluded due to missing information on lymph node status.
BVI, blood vessel invasion; LVI, lymphatic vessel invasion; No., number of cases; NS, not significant; PR, progesterone receptor.