Table 2

The 20 most relevant features selected based on maximising the relevance and minimising the redundancy. Colour component, colour space, region of interest and feature type are shown for each feature

Rank	Feature	Colour component	Colour space	ROI	Feature type
1	Nucleus/cytoplasm ratio	–	–	Cell	Geometric
2	Perimeter	–	–	Nucleus	Geometric
3	Equivalent diameter	–	–	Cell	Geometric
4	Kurtosis of the pseudo-granulometric curve	Cyan	CMYK	Cell	Granulometric
5	Skewness of the histogram	Blue	RGB	Cell	Stat first order
6	IMC1	Magenta	CMYK	Cell	Stat second order
7	SD of the histogram	Blue	RGB	Cell	Stat first order
8	Entropy 1 of the histogram	Magenta	CMYK	Cell	Stat first order
9	Skewness of the histogram	Green	RGB	Cell	Stat first order
10	Mean of the pseudo-granulometric curve	Black	CMYK	Cytoplasm	Granulometric
11	Mean of the histogram	Blue	RGB	Nucleus	Stat first order
12	Cluster shade	Saturation	HSV	Cell	Stat second order
13	Mean of the histogram	Magenta	CMYK	Cytoplasm	Stat first order
14	Homogeneity	Magenta	CMYK	Cell	Stat second order
15	Kurtosis of the histogram	Saturation	HSV	Cell	Stat first order
16	IMC1	Cyan	CMYK	Nucleus	Stat second order
17	Hairiness	–	–	Cytoplasm	Geometric
18	SD of the histogram	Saturation	HSV	Cell	Stat first order
19	Circularity	–	–	Nucleus	Geometric
20	Homogeneity	Black	CMYK	Cytoplasm	Stat second order

CMYK (cyan, magenta, yellow, black); HSV (hue, saturation, value); RGB (red, green, blue).
IMC1, information measure of correlation 1; ROI, regions of interest; Stat, statistical.