Infiltration of aberrant plasma cells in different diagnoses
| Diagnosis | Input (×106) (min–max) | PC infiltration (%) | aPC infiltration (%) | No of sorted aPC |
|---|---|---|---|---|
| MGUS (n=8) | 48.0 (32.0–57.0) | 0.20 (0.1–0.4) | 61.0 (7.0–96.1) | 10 123 (1116–76 453) |
| ALA (n=13) | 30.0 (13.7–40.0) | 1.10 (0.3–15.7) | 82.80 (30.7–99.6) | 22 846 (6837–691 234) |
| MM circulating PC (n=11) | 15.95 (9.75–56.4) | 2.60 (0.6–4.8) | 96.80 (52.2–99.8) | 68 641 (4240–193 119) |
| MM (n=11) | 10.0 (1.0–10.0) | 15.30 (2.0–75.0) | 97.40 (82.5–99.9) | 305 501 (21 435 –1 287 686) |
| MRD MM (n=14) | 37.2 (13–146) | 0.4 (0.1–6.8) | 13.3 (0.3–99.1) | 4000 (102–260 839) |
PC infiltration represents per cent of PC of mononuclear cells and aPC infiltration represents per cent of aPC of PC. Number of sorted cells represents number of aPC sorted and processed for isolation of nucleic acids.
Data are presented as median (minimum–maximum).
ALA, light chain amyloidosis; aPC, aberrant plasma cells; MGUS, monoclonal gammopathy of undetermined significance; MM, multiple myeloma; MRD, minimal residual disease; PC, plasma cells.