Immunohistochemical markers in the differential diagnosis of endometrial mesenchymal tumours
| vim | ER | PR | p53 | p16 | CD10 | desm | h-cald | Specific | |
| Endometrial mesenchymal tumours | |||||||||
| LGESS | + | + | + | wt | − | + | − | − | JAZF1–SUZ12 fusion |
| HGESS | + | − | − | wt | − | − | − | − |
YWHAE–NUTM2A/B fusion, cyclin D1, c-Kit, Ki-67 high |
| LM | + | + | + | wt | − | − | + | + | Actin |
| LMS | + | −/+ | −/+ | M>wt | + | − | + | + | Ki-67 high |
p53 M corresponds to intense and diffuse positivity in ≥60% of cells or complete negativity; p53 wt is the presence of rare cells weakly positive or positivity in <60% of cells.
desm, desmin; h-cald, h-caldesmon; HGESS, high-grade endometrial stromal sarcoma; LGESS, low-grade endometrial stromal sarcoma; LM, leiomyoma; LMS, leiomyosarcoma; M, mutant pattern; wt, wild-type pattern.