Association between outcome, in terms of BCSS and DMFS, and histologic grade, as assessed by VM and LM
| Parameter | BCSS | DMFI | ||||||
| VM grading | LM grading | VM grading | LM grading | |||||
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
| Grade* | 1.9 (1.6 to 2.3) | 1×10–13 | 2.4 (2.0 to 3.0) | 1×10–13 | 1.8 (1.5 to 2.1) | 1×10–13 | 2.1 (1.8 to 2.5) | 1.x10−13 |
| Tubules* | 2.8 (1.9 to 4) | 5.9×10–9 | 1.9 (1.5 to 2.4) | 9.58×10–9 | 2.6 (1.9 to 3.6) | 4.9×10–10 | 1.7 (1.4 to 2.1) | 4.6×10–8 |
| Pleomorphism* | 1.8 (1.5 to 2.2) | 6.2×10−11 | 2.7 (2 to 3.7) | 1×10–10 | 1.6 (1.3 to 1.8) | 1.6×10–9 | 2.2 (1.7 to 2.9) | 6.1×10–10 |
| Mitosis* | 1.5 (1.3 to 1.7) | 2.5×10–11 | 1.7 (1.5 to 1.9) | 1×10–13 | 1.4 (1.3 to 1.6) | 9.1×10–11 | 1.6 (1.4 to 1.8) | 1.0×10–13 |
| Grade† | 1.9 (1.6 to 2.3) | 1×10–13 | 1.8 (1.5 to 2.1) | 1.0×10–13 | ||||
| Tubules† | 2.2 (1.6 to 2.9) | 1.32×10–8 | 2.1 (1.6 to 2.6) | 3.6×10–9 | ||||
| Pleomorphism† | 1.8 (1.5 to 2.2) | 3.9×10–10 | 1.6 (1.3 to 1.9) | 7.42×10–9 | ||||
| Mitosis† | 1.8 (1.5 to 2.2) | 2.7×10–10 | 1.4 (1.2 to 1.6) | 2.2×10–9 | ||||
*VM grading first session (November 2016).
†VM grading second session (February 2017).
BCSS, breast cancer-specific survival; DMFS, distant metastasis-free survival; LM, light microscopy; VM, virtual microscopy.