Multivariate Cox proportional hazard analysis for predictors of BCSS and DMFS for histologic grade, as assessed by light microscopy and virtual microscopy sessions 1 and 2
| Variables | BCSS | DMFS | ||
| P value | HR (95% CI) | P value | HR (95% CI) | |
| Light microscopy | ||||
| Grade | <0.001 | 1.9 (1.5 to 2.3) | <0.001 | 1.6 (1.4 to 2.0) |
| Size | 0.004 | 1.4 (1.1 to 1.8) | <0.001 | 1.6 (1.3 to 2.0) |
| Nodal stage | <0.001 | 2.1 (1.5 to 2.3) | <0.001 | 2.0 (1.8 to 2.4) |
| ER status | 0.002 | 0.7 (0.5 to 0.9) | 0.024 | 0.7 (0.6 to 0.9) |
| Virtual microscopy 1 | ||||
| Grade | <0.001 | 1.7 (1.4 to 2.0) | <0.001 | 1.6 (1.3 to 1.8) |
| Size | 0.002 | 1.5 (1.2 to 1.9) | <0.001 | 1.6 (1.3 to 2.0) |
| Nodal stage | <0.001 | 2.2 (2.0 to 2.6) | <0.001 | 2.1 (1.9 to 2.5) |
| ER status | 0.010 | 0.7 (0.5 to 0.9) | 0.102 | 0.8 (0.6 to 1.0) |
| Virtual microscopy 2 | ||||
| Grade | <0.001 | 1.7 (1.4 to 2.0) | <0.001 | 1.6 (1.3 to 1.8) |
| Size | 0.005 | 1.4 (1.1 to 1.8) | <0.001 | 1.6 (1.3 to 2.0) |
| Nodal stage | <0.001 | 2.3 (1.9 to 2.6) | <0.001 | 2.1 (1.9 to 2.4) |
| ER status | 0.010 | 0.7 (0.5 to 0.9) | 0.107 | 0.8 (0.6 to 1.1) |
BCSS, breast cancer-specific survival; DMFS, distant metastasis-free survival; ER, oestrogen receptor.