Biochemical and Biophysical Research Communications
Regular Articlec-erbB-2 Gene Product Associates with Catenins in Human Cancer Cells
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Cadherin profiling for therapeutic interventions in Epithelial Mesenchymal Transition (EMT) and tumorigenesis
2018, Experimental Cell ResearchCitation Excerpt :The identified c-erbB-2 gene product is an oncogene product (homologous to EGFR) that provides the first evidence of cell-cell adhesion molecules interaction with oncogene product (Fig. 8 [51–55]. Tyrosine phosphorylation of catenins was found to be initiated by epidermal growth factor (EGF), which is known to be induced scattering of cancer cell lines, and a direct interaction between EGFRs and β-catenin [56–59]. Cadherin is a vital player in cancer phenotypes and continuing the efforts to understand the mode of function in context to tumor invasion and metastasis.
Clostridium difficile toxin B recombinant protein inhibits tumor growth and induces apoptosis through inhibiting Bcl-2 expression, triggering inflammatory responses and activating C-erbB-2 and Cox-2 expression in breast cancer mouse model
2018, Biomedicine and PharmacotherapyCitation Excerpt :For the in vivo experiments, the rcdtB inhibited the tumor growth and decreased the tumor volume. The previous studies [24,25] reported that C-erbB-2 confers an unfavorable prognosis to breast cancer patients, including increasing the cell mobility, disruption of tumor-cell adhesion, enhancing proliferation and inhibiting apoptosis. Our study showed that the C-erbB-2 expression was significantly decreased when undergoing the rcdtB treatment.
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2011, Annals of Thoracic SurgeryCitation Excerpt :Also, CA IX is associated with upregulation of epidermal growth factor receptor, c-erbB-2, and mucin 1 [19]. All three proteins disrupt cell–cell adhesion by degrading the catenin–cadherin complex, or the integrin-mediated cell adhesion system [20]. The c-erbB2 proteins are well known to mediate cellular motility and migration, and mucin 1is involved in endothelial adhesion and cancer metastasis [21].
Molecular pathological approach to cancer epigenomics and its clinical application
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