Regular ArticleLong-Term Low-Dose IL-2 Enhances Immune Function in Common Variable Immunodeficiency
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T-Cell-Dependent Antibody Response Assay: Biology, Methods, and Application
2018, Comprehensive Toxicology: Third EditionAntibody forming cells and plasmablasts in peripheral blood in CVID patients after vaccination
2011, VaccineCitation Excerpt :The other group investigated the specific IgG production ability in CVID patients under immunoglobulin substitution therapy after vaccination against tick-borne encephalitis virus [32]. Immunization with a protein neoantigen, e.g. bacteriophage, and investigation of immune response with neutralization assay brought similar results [39,40]. Nevertheless, there is very little quantitative data correlating individual vaccination responses to proposed classifications of CVID [29,39,41].
Regulatory T cell dysfunction in subjects with common variable immunodeficiency complicated by autoimmune disease
2009, Clinical ImmunologyCitation Excerpt :However, since CVID is a polygenic disease and since T cells are important to B cell development and function, we focused on T cell phenotyping. In addition, other laboratories have found that multiple T cell abnormalities ranging from loss of CD4+ naïve cells, disrupted T cell receptor B variable repertoires, to altered cytokine production existing in CVID subjects [3,18–20]. Therefore, we designed our studies to test whether a specific subtype of T cells, the regulatory T cell, was impaired in CVID patients with autoimmune disease.
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