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Role of Cbfa1 in osteoblast differentiation and function

https://doi.org/10.1006/scdb.2000.0188Get rights and content

Abstract

Among the multiple cell lineages whose differentiation is affected by a runt-related gene the osteoblast is a relative newcomer. Molecular biology, developmental biology and mouse and human genetic studies have demonstrated that Cbfa1 is a critical regulator of osteoblast differentiation in vertebrates. Cbfa1 is not only a differentiation factor but also a regulator of bone formation by differentiated osteoblasts beyond development. Thus, Cbfa1 controls osteogenesis at multiple stages.

References (24)

  • DA Towler et al.

    Activity of the rat osteocalcin basal promoter in osteoblastic cells is dependent upon homeodomain and CP1 binding motifs

    Mol Endocrinol

    (1994)
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      Citation Excerpt :

      The lipopeptide produced by CPNE1 provides structural support during cell membrane fusion and other cell life activities (Koukalová et al., 2018). Transcription factors from the RUNX family, especially RUNX1, also known as Cbfa1, are fundamental parts of expressed groups of genes critical for progression of hematopoietic and osteogenic cell lineages (Tracey and Speck, 2000; Karsenty, 2000; Woolf et al., 2003). The first intron of GNG3 has a sequence element that is consensus with RUNX1.

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