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Skeletal Muscle Metabolism in Exercise and Diabetes pp 63–71Cite as

Molecular Mechanisms Involved in GLUT4 Translocation in Muscle during Insulin and Contraction Stimulation

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 441))

Abstract

Studies in mammalian cells have established the existence of numerous intracellular signaling cascades that are critical intermediates in the regulation of various biological functions. Over the past few years considerable research has shown that many of these signaling proteins are expressed in skeletal muscle. However, the detailed mechanisms involved in the regulation of glucose transporter (GLUT4) translocation from intracellular compartments to the cell surface membrane in response to insulin and contractions in skeletal muscle are not well understood.

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Authors and Affiliations

  1. Experimental Diabetes, Metabolism, and Nutrition Section, Diabetes Branch, NIDDK, National Institutes of Health, Bethesda, Maryland, USA

    S. W. Cushman

  2. Joslin Diabetes Center, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA

    L. J. Goodyear

  3. Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts, USA

    P. F. Pilch

  4. Laboratory of Neurobiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA

    E. Ralston

  5. Copenhagen Muscle Research Centre, Department of Medical Physiology, The Panum Institute University of Copenhagen, Denmark

    H. Galbo & T. Ploug

  6. Copenhagen Muscle Research Centre, Department of Human Physiology, The August Krogh Institute, University of Copenhagen, Denmark

    Søren Kristiansen

  7. Division of Cell Biology, Hospital for Sick Children, Toronto, Canada

    Amira Klip

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  1. Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen, Denmark

    Erik A. Richter , Bente Kiens , Henrik Galbo  & Bengt Saltin , ,  & 

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Cushman, S.W. et al. (1998). Molecular Mechanisms Involved in GLUT4 Translocation in Muscle during Insulin and Contraction Stimulation. In: Richter, E.A., Kiens, B., Galbo, H., Saltin, B. (eds) Skeletal Muscle Metabolism in Exercise and Diabetes. Advances in Experimental Medicine and Biology, vol 441. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1928-1_6

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