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Cancer Epidemiology pp 387–407Cite as

Linking the Kaposi's Sarcoma-Associated Herpesvirus (KSHV/HHV-8) to Human Malignancies

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 471))

Summary

In 1994, the Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) was identified as the etiologic agent of Kaposi's sarcoma (KS). KSHV has since been associated with two additional malignancies: primary effusion lymphoma and multicentric Castleman's disease. In this chapter, we describe the current understanding of the pathogenesis, transmission, and prevalence of KSHV, and its association mainly with KS. We describe evidence demonstrating that KSHV is a causative agent for KS, and we present other factors that possibly contribute to the incidence of KS. We compare worldwide data on the prevalence of KS and of KSHV infection. Specific viral genes that may induce KS tumors or enable their growth also are described. Finally, we discuss the implications of the transmission modes and epidemiology of this virus on recommendations for KSHV screening of tissues and blood products before transplantation or transfusion.

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Acknowledgments

We regret the omission of many research papers due to space constraints. We thank Ella Gindy for graphical assistance. Work in our laboratory is supported by the Israeli Ministry of Justice, the Israeli Ministry of Health, the Israel Association for Cancer Research, and by the Israel Science Foundation.

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Authors and Affiliations

  1. The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel

    Inna Kalt, Shiri-Rivka Masa & Ronit Sarid

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  1. Inna Kalt
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  2. Shiri-Rivka Masa
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  1. Division of Cancer Control and Population Sciences Bethesda, Maryland, 20892, USA

    Mukesh Verma PhD

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Kalt, I., Masa, SR., Sarid, R. (2009). Linking the Kaposi's Sarcoma-Associated Herpesvirus (KSHV/HHV-8) to Human Malignancies. In: Verma, M. (eds) Cancer Epidemiology. Methods in Molecular Biology, vol 471. Humana Press. https://doi.org/10.1007/978-1-59745-416-2_19

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  • DOI: https://doi.org/10.1007/978-1-59745-416-2_19

  • Publisher Name: Humana Press

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