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Carcinoembryonic antigen: Function in metastasis by human colorectal carcinoma

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Abstract

Carcinoembryonic antigen (CEA) is a glycoprotein that has been useful as a tumor marker to predict recurrence in gastrointestinal malignancies, but whose biological function has not been elucidated. With the recent evidence that CEA is a member of the immunoglobulin supergene family, CEA may be involved in intercellular recognition and binding. This review examines the role that CEA plays in the development of mestastases by colorectal carcinoma.

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  1. Department of Surgery, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA

    Milburn Jessup & Peter Thomas

  2. Laboratory of Cancer Biology, Department of Surgery, New England Deaconess Hospital, 02215, Boston, MA, USA

    Milburn Jessup & Peter Thomas

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  1. Milburn Jessup
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Supported by grant RO1CA42587 from the U.S. Department of Health and Human Services.

Supported by grants RO1CA44586 and PO1CA44704 from the U.S. Department of Health and Human Services.

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Jessup, M., Thomas, P. Carcinoembryonic antigen: Function in metastasis by human colorectal carcinoma. Cancer Metast Rev 8, 263–280 (1989). https://doi.org/10.1007/BF00047341

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