Summary
Morphology of blood vessels in cancer of the larynx, which as other solid tumors has great neoangiogenic abilities, was studied on microcorrosion casts in SEM. Most evident changes of the endothelial patterns were seen on the casts of capillaries, venules, and veins.
Capillaries, especially the newly formed, are the most numerous constituent of the vasacular bed in all zones of cancer of the larynx. These vessels exhibit great morphological differentiation varying from the single, blind-ended pipes via relatively long hairpin loops spirally twisted in the long axis, to strongly spiralled and convoluted loops, resembling pseudoglomeruli. The newly formed capillaries deriving predominantly from the host's capillaries, venules, and veins have an embryonal character.
It seems resonable to presume that the neoangiogenesis process triggered by active influence of the tumor angiogenesis factor, is in principle, a repetition of the mechanism of the embryonal angiogenesis.
Zusammenfassung
Mit Hilfe der REM wurde die Morphologie der Innenabdrucke von Blutgefäßen bei Kehlkopfkarzinom untersucht. Als bösartige Geschwulst produziert es TAF und ist somit fähig, den Prozeß der Neoangiogenesis in Gang zu setzen. Die größten Unterschiede in den Replika-Mustern des Endothels im Vergleich mit denjenigen von normalem Gewebe wurden bei Kapillaren, Venolen und Venen festgestellt. In allen Zonen des Kehlkopfkarzinoms machen Kapillargefäße den größten Anteil des Blutgefäßlagers aus. Auch erweisen sie die stärkste morphologische Differenzierung sowohl im Fall von blind endenden, kolbenförmig im distalen Abschnitt erweiterten Röhrchen als auch bei Schlingen, die durch Gefäße recht verschiedenen Durchmessers gebildet werden, und deren Arme während ihres Wachstums einer oft sehr starken Verwindung und zusätzlichen Biegungen unterliegen.
Die sich neu bildenden Kapillargefäße, die vor allem dem veno-kapillaren Gefäßlager der Umgebung entstammen, entsprechen dem Typ embryonaler Blutgefäße. Deshalb ist es sehr wahrscheinlich, daß der durch aktives Einwirken von TAF hervorgerufene Prozeß der Neoangiogenese im Prinzip einer Repetition der Mechanismen der embryonalen Angiogenese gleichkommt.
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Abbreviations
- SEM:
-
Scanning electron microscopy
- TAF:
-
tumor angiogenesis factor
- EPF:
-
endothelial proliferating factor
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Kuś, J., Miodoński, A., Olszewski, E. et al. Morphology of arteries, veins, and capillaries in cancer of the larynx. J Cancer Res Clin Oncol 100, 271–283 (1981). https://doi.org/10.1007/BF00410688
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DOI: https://doi.org/10.1007/BF00410688