Summary
A clinicopathologic analysis of 103 liposarcomas from the lower extremity and the retroperitoneum was presented. The tumors were divided according to their histologic pattern into four groups: liposarcomas of the myxoid cell, round cell, well-differentiated, and pleomorphic types. The various histologic groups differed considerably in location, age distribution, and clinical behavior. The myxoid and round cell types were most common in the lower extremity, while the majority of well-differentiated and pleomorphic liposarcomas originated in the retroperitoneum. The median age of patients with myxoid and round cell tumors was also about 11 years less than that of patients with well-differentiated and pleomorphic liposarcomas.
Follow-up information obtained in 91 of the patients revealed that all liposarcomas irrespective of type had recurred in more than 50% of the patients. Yet, the 5-year survival rates of the myxoid and well-differentiated types were almost four times those of the round cell and pleomorphic types, and the over-all survival rates were considerably better in the liposarcomas of the lower extremity than in those of the retroperitoneum.
Zusammenfassung
Der Arbeit liegen 103 Liposarkome der unteren Gliedmaßen und des Retroperitonealraums zugrunde. Nach dem histologischen Struktur- und Zellbild werden 4 Typen unterschieden: der myxoide, der Rundzell-, der hochdifferenzierte und der pleomorphe Typus. Die histologischen Varianten zeigen in bezug auf Lokalisation, Alter des Patienten und klinischem Verhalten beträchtliche Unterschiede. Der myxoide und Rundzelltypus kommt besonders an den unteren Gliedmaßen vor, während die Mehrzahl der hochdifferenzierten und pleomorphen Sarkome vom Retroperitonealraum ihren Ausgang nehmen. Das mittlere Lebensalter der Patienten mit myxoiden und Rundzell-Liposarkomen liegt 11 Jahre tiefer als dasjenige der Patienten mit hochdifferenzierten und pleomorphen Liposarkomen. Die Katamnesen von 91 Patienten zeigen, daß Liposarkome, unabhängig vom histologischen Typus, in 50% der Fälle rezidivieren. Die 5-Jahresüberlebensdauer ist bei dem myxoiden und hochdifferenzierten Typus viermal höher als bei dem Rundzell- und pleomorphen Typus. Gesamthaft liegen die Überlebenszeiten der Träger der Liposarkome der unteren Gliedmaßen erheblich über denjenigen des Retroperitonealraumes.
Similar content being viewed by others
References
Ackerman, L. V.: Multiple primary liposarcomas. Amer. J. Path.20, 789 (1944).
Adair, F. E., G. T. Pack andJ. H. Farrior: Lipomas. Amer. J. Cancer16, 1104 (1932).
Burow: Lipoma myxomatodes telangiectaticum des Oberschenkels. Virchows Arch. path. Anat.38, 565–568 (1867).
Delamater, J.: Mammoth tumor. Cleveland med. Gaz.1, 31 (1859).
Enterline, H. T., J. D. Culberson, D. B. Rochlin andL. W. Brady: Liposarcoma — a clinical and pathological study of 53 cases. Cancer (Philad.)13, 932–950 (1960).
Ewing, J.: Neoplastic diseases. Philadelphia: W. B. Saunders Company 1928.
—: Fascial sarcoma and intermuscular myxoliposarcoma. A.M.A. Arch. Surg.31, 507–520 (1935).
Ewing, M. R., andC. V. Harrison: Mesenchymoma. Brit. J. Surg.44, 408–414 (1957).
Flemming, A.: Quoted byWassermann.
Friedman, M., andJ. W. Egan: Effect of irradiation on liposarcoma. Acta radiol. (Stockh.)54, 225–239 (1960).
Gilmour, J. R.: A recurrent tumour of mesenchyme in an adult. J. Path. Bact.55, 495–498 (1943).
Goormaghtigh, N., P. Vanderlinden andR. de Puysseleyr: Lipocytomes et lipocytoses (lipoblastomes et lipoblastoses). Contribution à l'étude des liposarcomes profonds. Cancer (Brux.)13, 3–48 (1936–37).
Gricouroff, G.: Le diagnostic histologique du lipome embryonnaire. Bull. Ass. franç. Cancer27, 251–259 (1938).
Hotz, F.: Liposarcomas. Cancer (Philad.)6, 1103–1109 (1958).
Howard, W. R., andE. B. Helwig: Angiolipoma. A.M.A. Arch. Derm.82, 924–931 (1960).
Jaffé, R. H.: Recurrent lipomatous tumors of the groin. Liposarcoma and lipoma pseudomyxomatodes. A.M.A. Arch. Path.1, 381–387 (1926).
Kauffman, S. L., andA. P. Stout: Lipoblastic tumors of children. Cancer (Philad.)12, 912–925 (1959).
Kretschmer, H. L.: Retroperitoneal lipo-fibro-sarcoma in a child. J. Urol. (Baltimore)43, 61–74 (1940).
Mariotti, A., andN. Vertaccini: A study of the pathogenesis of liposarcoma. Arch. ital. Pat. Clin. Tumori3/5, 6, 7, 1456–1468 (1959).
Mowry, R. W.: Improved procedure for the staining of acidic polysaccharides by Müller's colloidal (hydrous) ferric oxide and its combination with the Feulgen and the periodic acid-Schiff reactions. Lab. Invest.7, 566–576 (1958).
Pack, G. T., andJ. C. Pierson: Liposarcoma, a study of 105 cases. Surgery36, 687–712 (1954).
Plaut, A.: Myelolipoma in the adrenal cortex (myeloadipose structures). Amer. J. Path.34, 487–515 (1958).
Robertson, H. E.: Lipoma myxomatodes. J. med. Res.35, 131–146 (1916).
Rosenbaum: In discussion of A. P. Stout's Seminar on Tumors of Soft Tissues, p. 24. Chicago: American Society Clinical Pathologists 1953.
Sampson, C. C., E. H. Saunders, W. E. Green andJ. R. Laurey: Liposarcoma developing in a lipoma. A.M.A. Arch. Path.69, 506–510 (1960).
Shuman, R.: Mesenchymal tumors. In: Pathology (W. A. D. Anderson, Ed.), pp. 461–480. St. Louis: C. V. Mosby Co. 1961.
Siegmund, H.: Lipoblastische Sarkomatose. Virchows Arch. path. Anat.293, 458–463 (1934).
Siperstein, M. D.: Inter-relationship of glucose and lipid metabolism. Amer. J. Med.26, 685–702 (1959).
Starkloff, G. B., J. A. Saxton andR. E. Johnson: Liposarcoma of an extremity associated with multiple subcutaneous lipomas. Ann. Surg.133, 261–266 (1951).
Sternberg, S. S.: Liposarcoma arising within a subcutaneous lipoma. Cancer (Philad.)5, 975–978 (1952).
Stout, A. P.: Liposarcoma — the malignant tumor of lipoblasts. Ann. Surg.119, 86–107 (1944).
—: Seminar on Tumors of the Soft Tissues. Chicago: American Society Clinical Pathologists 1953.
Tanaka, N., andW. C. Chen: A case of angiolipomyxosarcoma arising from traumatic hematoma of the thigh. Gann45, 265–267 (1954).
Tedeschi, C. G.: Systemic multicentric lipoblastosis. A.M.A. Arch. Path.42, 320–337 (1946).
Vellios, F., J. M. Baez andH. B. Shumacker: Lipoblastomatosis: a tumor of fetal fat different from hibernoma. Report of a case with observations of the embryogenesis of human adipose tissue. Amer. J. Path.34, 1149–1159 (1958).
Virchow, R.: Die krankhaften Geschwülste. Berlin: A. Hirschwald 1863.
—: Myxoma lipomatodes malignum. Virchows Arch. path. Anat.32, 545–546 (1865).
Wahlendorf, A. R. L. v.: Über retroperitoneale Lipome. Langenbecks Arch. klin. Chir.115, 751–768 (1921).
Waldeyer, W.: Großes Lipo-myxom des Mesenteriums mit secundären sarcomatösen Herden in der Leber und Lunge. Virchows Arch. path. Anat.32, 543–544 (1865).
Wassermann, F.: Die Fettorgane des Menschen, Entwicklung, Bau und systematische Stellung des sogenannten Fettgewebes. Z. Zellforsch.3, 235–328 (1926).
Weerd, J. H. de, andM. B. Dockerty: Lipomatous retroperitoneal tumors. Amer. J. Surg.84, 397–407 (1952).
Wells, H. G.: Adipose tissue, a neglected subject. J. Amer. med. Ass.114, 2177–2183, 2284–2289 (1940).
Winslow, D. J., andF. M. Enzinger: Hyaluronidase-sensitive acid mucopolysaccharides in liposarcomas. Amer. J. Path.37, 497–505 (1960).
Wright, C. J. E.: Liposarcoma arising in a single lipoma. J. Path. Bact.60, 483 (1948).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Enzinger, F.M., Winslow, D.J. Liposarcoma. Virchows Arch. path Anat. 335, 367–388 (1962). https://doi.org/10.1007/BF00957030
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00957030