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Helicobacter pylori infection induces a decrease in immunoreactive-somatostatin concentrations of human stomach

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Abstract

Immunoreactive-somatostatin (ir-somatostatin) concentrations of the gastric mucosa and gastric juice withHelicobacter pylori infection were measured in the human stomach. One hundred seventy-one patients (106 males, 65 females;, mean age, 52.0; range, 19–84 years) were registered. Gastric juice and mucosa were obtained with the usual endoscopy procedure. Somatostatin concentration was measured by radioimmunoassay. The irsomatostatin concentrations in theH. pylori-negative group were significantly higher than in the positive group gastric mucosa, whereas its levels in gastric juice tended to decrease withH. pylori infection. There was an inverse correlation between luminal ammonia levels and ir-somatostatin concentrations of the gastric mucosa. On the other hand, ir-somatostatin concentrations of the gastric mucosa significantly decreased with chronic and active inflammatory change. This decrease was not correlated with the grade of active inflammation, which was in close relation, toH. pylori infection, but with the grade of chronic inflammation. These results indicate thatH. pylori may reduce ir-somatostatin concentrations of the human stomach and that its effect is partly mediated via luminal ammonia produced byH. pylori.

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References

  1. Warren JR, Marshall BJ: Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet 1:1273–1275, 1983

    Google Scholar 

  2. Marshall BJ, Armstrong JA, McGechie DB, Glancy RJ: Attempt to fullfil Koch's postulates for pyloricCampylobacter. Med J Aust 142:436–439, 1985

    Google Scholar 

  3. Morris A, Nicholson G: Ingestion, ofCampylobacter pyloridis causes gastritis and raised fasting gastric pH. Am J Gastroenterol 82:192–199, 1987

    Google Scholar 

  4. Buck GE, Gourley WK, Lee WK, Subramanyam K, Latimer JM, DiNuzzo AR: Relation ofCampylobacter pyloridis to gastritis and peptic ulcer. J Infect Dis 153:664–669, 1986

    Google Scholar 

  5. Marshall BJ, McGechie DB, Rogers PA, Glancy RJ: PyloricCampylobacter infection and gastroduodenal disease. Med J Aust 142:439–444, 1985

    Google Scholar 

  6. Marshall BJ, Goodwin CS, Warren JR, Murray R, Blincow ED, Blackbourn SJ, Phillips M, Waters TE, Sanderson CR: Prospective double-blind trial of duodenal ulcer relapse after eradication, ofCampylobacter pylori. Lancet 2:1437–1442, 1988

    Google Scholar 

  7. Coghlan JG, Gilligan D, Humphries H, McKenna D, Dooley C, Sweeney E, Keane C, O'Morain C:Campylobacter pylori and recurrence of duodenal ulcers—a 12-month, follow-up study. Lancet 2:1109–1111, 1987

    Google Scholar 

  8. Hazell SL, Lee A:Campylobacter pyloridis, urease, hydrogen ion back diffusion, and gastric ulcers. Lancet 2:15–17, 1986

    Google Scholar 

  9. Marshall BJ, Langton SR: Urea hydrolysis in patients withCampylobacter pyloridis infection. Lancet 1:965–966, 1986

    Google Scholar 

  10. Lucey MR: Endogenous somatostatin and the gut. Gut 27:457–467, 1986

    Google Scholar 

  11. Arnold R, Lankisch PG: Somatostatin and the gastrointestinal tract. Clin Gastroenterol 9:733–753, 1980

    Google Scholar 

  12. Chayvialle JAP, Descos F, Bernard C, Martin A, Barbe C, Partensky C: Somatostatin in mucosa of stomach and duodenum in gastroduodenal disease. Gastroenterology 75:13–19, 1978

    Google Scholar 

  13. Levi S, Beardshall K, Haddad G, Playford R, Ghosh P, Calam J:Campylobacter pylori and duodenal ulcers: The gastrin link. Lancet 1:1167–1168, 1989

    Google Scholar 

  14. Smith JTL, Pounder RE, Nwokolo CU, Lanzon-Miller S, Evans DG, Graham DY, Evans DJ: Inappropriate hypergastrinaemia in asymptomatic healthy subjects infected withHelicobacter pylori. Gut 31:522–525, 1990

    Google Scholar 

  15. Graham DY, Opekun A Lew GM, Evans DJ, Klein PD, Evans DG: Ablation of exaggerated meal-stimulated gastrin release in duodenal ulcer patients after clearance ofHelicobacter (Campylobacter.) pylori infection. Am J Gastroenterol 85:394–398, 1990

    Google Scholar 

  16. Schindler R: Classification of chronic gastritis with special reference to the gastroscopic method studied based on 1,200 cases. Arch Intern Med 57:959–978, 1936

    Google Scholar 

  17. Whitehead R, Truelove SC, Gear MWL: The histological diagnosis of chronic gastritis in fibreoptic gastroscope biopsy specimens. J Clin Pathol 25:1–11, 1972

    Google Scholar 

  18. Hui WM, Lam SK, Ho J, Ng MMT, Lui I, Lai CL, Lok ASF, Lau WY, Poon GP, Choi S, Choi TK: Chronic antral gastritis in duodenal ulcer, natural history and treatment with prostaglandin E1. Gastroenterology 91:1095–1101, 1986

    Google Scholar 

  19. Levitzki A: Determination of submicro quantities of ammonia. Anal Biochem 33:335–340, 1970

    Google Scholar 

  20. Itoh M, Mitsuma T, Tomita A: Studies on the measurements of somatostatin by radioimmunoassay. Folia Endocrinol Jpn 53:1106–1117, 1977 (in Japanese, with English abstract)

    Google Scholar 

  21. Larsson L-I, Goltermann N, Magistris L, Rehfeld JF, Schwartz TW: Somatostatin cell processes as pathways for paracrine secretion. Science 205:1393–1395, 1979

    Google Scholar 

  22. Penman E, Wass JAH, Butler MG, Penny ES, Price J, Wu P, Rees LH: Distribution and characterisation, of immunoreactive somatostatin in human gastrointestinal tract. Regul Pept 7:53–65, 1983

    Google Scholar 

  23. Degertekin H, Ertan A, Akdamar K, Groot K, Godiwala T, Mather FJ, Arimura A: Luminal gastric somatostatin-like immunoreactivity in response to various stimuli in man. Dig Dis Sci 31:833–839, 1986

    Google Scholar 

  24. Uvnäs-Wallensten K, Efendic S, Johansson C, Sjödin L, Cranwell PD: Effect of, intraluminal pH on the release of somatostatin and gastrin into antral, bulbar and ileal pouches of conscious dogs. Acta Physiol Scand 110:391–400, 1980

    Google Scholar 

  25. Uvnäs-Wallensten K, Efendic S, Luft R: Vagal release of somatostatin into antral lumen of cats. Acta Physiol Scand 99:126–128, 1977

    Google Scholar 

  26. McIntosh C, Arnold R, Bothe E, Becker H, Kobberling J, Creutzfeldt W: Gastrointestinal somatostatin: extraction and radioimmunoassay in different species. Gut 19:655–663, 1978

    Google Scholar 

  27. Bryant MG, Bloom SR, Polak JM, Hobbs S, Domschke W, Domschke S, Mitznegg P, Ruppin H, Demling L: Measurement of gut hormonal peptides in biopsies from human stomach and proximal small intestine. Gut 24:114–119, 1983

    Google Scholar 

  28. Creutzfeldt W, Arnold R: Somatostatin and the stomach: Exocrine and endocrine aspects. Metabolism 27:1309–1315, 1978

    Google Scholar 

  29. Sumioka M: Somatostatin in gastric juice and study on its clinical significance. J Hiroshima Med Assoc 33:1073–1089, 1985 (in Japanese, with English abstract)

    Google Scholar 

  30. Murakami M:Campylobacter pylori and ammonia. Saishinigaku 44:279–283, 1989 (in Japanese, with English abstract)

    Google Scholar 

  31. Kochiyama T: Clinical study ofCampylobacter, pylori in stomach disease. Gastroenterol Endosc 31:3–13, 1989 (in Japanese, with English abstract)

    Google Scholar 

  32. Chittajallu RS, Neithercut WD, Macdonald AMI, McColl KEL: Effect of increasingHelicobacter pylori ammonia production by urea infusion on plasma gastrin concentrations. Gut 32:21–24, 1991

    Google Scholar 

  33. Graham DY, Opekun A, Lew GM, Klein PD, Walsh JH:Helicobacter pylori-associated exaggerated gastrin release in duodenal ulcer patients. Gastroenterology 100:1571–1575, 1991

    Google Scholar 

  34. Schubert ML, Edwards NF, Makhlouf GM: Regulation of gastric somatostatin secretion in the mouse by luminal acidity: A local feedback mechanism. Gastroenterology 94: 317–322, 1988

    Google Scholar 

  35. Wyatt JI, Rathbone BJ, Green DM, Primrose J: Raised fasting serum gastrin in chronic gastritis is independent ofCampylobacter pylori status and duodenal ulceration. Gut 30:A1483, 1989

    Google Scholar 

  36. Soll AH, Amirian, DA, Park J, Elashoff JD, Yamada T: Cholecystokinin potently releases somatostatin from canine fundic mucosal cells in short-term culture. Am J Physiol 248:G569-G573, 1985

    Google Scholar 

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Authors and Affiliations

  1. First Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan

    Hiroshi Kaneko MD, Koichi Nakada MD, Terunori Mitsuma MD, Kiyoshi Uchida MD, Atsushi Furusawa MD, Yoshiaki Maeda MD & Kimitomo Morise MD

  2. Fourth Department of Internal Medicine, Aichi Medical University, 21 Karimata, Yazako, Nagakute-cho, Aichi-gun, 480-11, Aichi-ken, Japan

    Hiroshi Kaneko MD, Koichi Nakada MD, Terunori Mitsuma MD, Kiyoshi Uchida MD, Atsushi Furusawa MD, Yoshiaki Maeda MD & Kimitomo Morise MD

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  1. Hiroshi Kaneko MD
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  2. Koichi Nakada MD
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  3. Terunori Mitsuma MD
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  4. Kiyoshi Uchida MD
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Kaneko, H., Nakada, K., Mitsuma, T. et al. Helicobacter pylori infection induces a decrease in immunoreactive-somatostatin concentrations of human stomach. Digest Dis Sci 37, 409–416 (1992). https://doi.org/10.1007/BF01307736

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  • DOI: https://doi.org/10.1007/BF01307736

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